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• Otra segunda fuente natural son los protistas del género Au-                                                               ANALES
  rantiochytrium sp. 18W-13a que acumulan un 13% de su peso                                                                        RANF
  como escualeno (28).
  • Nuevos desarrollos tecnológicos a partir de caña de azúcar                                                                                 www.analesranf.com
  como el que ha desarrollado la empresa Amyris Biotecnología,
  (Emeryville, CA, USA) o la generación de nuevas levaduras por                Fernández-Juan M, Navarro MA, et al. Squalene: Current Knowledge
  biología sintética que lo acumulen (29) y que ya explota la em-              and Potential Therapeutical Uses. First edition ed. New York: NOVA;
  presa Enepret Inc (Lexington, KY, USA) muestran la importancia               2010.
  de producir este compuesto de la máxima pureza, bajo coste y             10. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apo
  con el menor impacto ambiental.                                              E. Evaluation of lesional development and progression. Arterioscler
6. CONCLUSIONES                                                                Thromb. 1994;14:141-7.
  • El escualeno es más que un intermediario metabólico en la              11. Sarria AJ, Surra JC, Acin S, Carnicer R, Navarro MA, Arbones-Mainar
  biosíntesis de colesterol, fitosteroles y terpenos.                          JM, et al. Understanding the role of dietary components on atheros-
  • Posee una amplia gama acciones importantes en varios siste-                clerosis using genetic engineered mouse models. Front Biosci.
  mas biológicos.                                                              2006;11:955-67.
  • Su amplio uso industrial en cosmética y adyuvante de vacunas           12. Demetrius L. Of mice and men. When it comes to studying ageing
  plantea importantes retos medioambientales.                                  and the means to slow it down, mice are not just small humans. EMBO
  • Son esos desafíos los que actúan como un motor de desarrollo               reports. 2005;6:S39-S44.
  biotecnológico para una producción más sostenible de este com-           13. Willett WC. Diet and health: what should we eat? Science.
  puesto.                                                                      1994;264:532-7.
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                                                                               Mouse Models. Mol Nutr Food Res. 2020;64:e2000354.

          Squalene, a vibrant molecule despite its one-hundred-five-year

210 old discovery
          Jesús De la Osada García
          An. Real Acad. Farm. Vol. 87. Nº 2 (2021) · pp. 205-211
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