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ANALES
RANF
www.analesranf.com
7. LISTA DE ABREVIATURAS
AT1: receptor 1 para angiotensina II
CMLV: células musculares lisas vasculares
DOCA: acetato de deoxicorticosterona
ETBR: receptor B para endotelina
GPCR: receptores acoplados a proteínas G
GPER1: receptor 1 de estrógenos acoplado a proteínas G
GRK2: quinasa 2 de receptores acoplados a proteínas G
IGF1R: receptor para el factor de crecimiento similar a insulina 1
MR: receptor mineralocorticoide
Nox: NADPH oxidasa
PDGFR: receptor para el factor decrecimiento derivado de plaquetas
ROS: especies reactivas de oxígeno, del inglés reactive oxygen species
SOD: superoxido dismutasa
T2DM: diabetes mellitus tipo 2
8. AGRADECIMIENTOS
AMB está financiada por el Ministerio de Economía, Industria
y Competitividad (SAF2016-80305P), Instituto de Salud Carlos III
(PI13/01488; CIBER de Enfermedades Cardiovasculares,
CB16/11/00286) y Comunidad de Madrid (B2017/BMD-3676), Fondo
Social Europeo (FSE), Fondo Europeo de Desarrollo Regional (FEDER)
a way to build Europe. RR-D está financiada por un contrato Juan de
la Cierva Reincorporación ((IJCI-2017-31399).
9. REFERENCIAS
1. Jaisser F, Farman N. Emerging Roles of the Mineralocorticoid Receptor in
Pathology: Toward New Paradigms in Clinical Pharmacology. Pharmacol
Rev. 2016; 68(1):49-75.
2. DuPont JJ, Jaffe IZ. 30 years of the mineralocorticoid receptor: The role of 17. Hashikabe Y, Suzuki K, Jojima T, Uchida K, Hattori Y. Aldosterone impairs
the mineralocorticoid receptor in the vasculature. J Endocrinol. 2017;
234(1):T67-T82.
3. Briet M, Schiffrin EL. Vascular actions of aldosterone. J Vasc Res. 2013;
50(2):89-99.
4. Armani A, Marzolla V, Fabbri A, Caprio M. Cellular mechanisms of MR re-
gulation of adipose tissue physiology and pathophysiology. J Mol Endocri-
nol. 2015; 55(2):R1-10.
5. van der Heijden CDCC, Deinum J, Joosten LAB, Netea MG, Riksen NP. The
mineralocorticoid receptor as a modulator of innate immunity and athe-
rosclerosis. Cardiovasc Res. 2018; 114(7):944-953.
6. Ruhs S, Nolze A, Hübschmann R, Grossmann C. 30 years of the mineralo-
corticoid receptor: Nongenomic effects via the mineralocorticoid receptor. J
Endocrinol. 2017; 234(1):T107-T124.
7. DuPont JJ, McCurley A, Davel AP, McCarthy J, Bender SB, Hong K, Yang Y,
Yoo JK, Aronovitz M, Baur WE, Christou DD, Hill MA, Jaffe IZ. Vascular mi-
neralocorticoid receptor regulates microRNA-155 to promote vasoconstric-
Receptor mineralocorticoide extrarrenal. Una posi-
ble nueva diana para combatir el daño vascular.
Ana M. Briones y Raquel Rodrigues-Díez
An Real Acad Farm Vol. 86. Nº 1 (2020) · pp. 61 -73
tion and rising blood pressure with aging. JCI Insight. 2016;
1(14):e88942.
8. Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison
DG, Bhatnagar A; American Heart Association Council on Basic Cardiovas-
cular Sciences. Measurement of Reactive Oxygen Species, Reactive Nitrogen
Species, and Redox-Dependent Signaling in the Cardiovascular System: A
Scientific Statement From the American Heart Association. Circ Res. 2016;
119(5):e39-75.
9. Queisser N, Schupp N. Aldosterone, oxidative stress, and NF-kB activation
in hypertension-related cardiovascular and renal diseases. Free Radic Biol
Med. 2012; 53(2):314-27.
10. Callera GE, Montezano AC, Yogi A, Tostes RC, He Y, Schiffrin EL, Touyz
RM. c-Src-dependent nongenomic signaling responses to aldosterone are
increased in vascular myocytes from spontaneously hypertensive rats.
Hypertension. 2005; 46(4):1032-8.
11. Fan C, Kawai Y, Inaba S, Arakawa K, Katsuyama M, Kajinami K, Yasuda
T, Yabe-Nishimura C, Konoshita T, Miyamori I. Synergy of aldosterone and
high salt induces vascular smooth muscle hypertrophy through up-regula-
tion of NOX1. J Steroid Biochem Mol Biol. 2008; 111(1-2):29-36.
12. Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold
JA. Aldosterone increases oxidant stress to impair guanylyl cyclase activity
by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem.
2009; 284(12):7665-72.
13. Fu Y, Shi G, Wu Y, Kawai Y, Tian Q, Yue L, Xia Q, Miyamori I, Fan C. The
mitochondria mediate the induction of NOX1 gene expression by aldoste-
rone in an ATF-1-dependent manner. Cell Mol Biol Lett. 2011; 16(2):226-
35.
14. Muehlfelder M, Arias-Loza PA, Fritzemeier KH, Pelzer T. Both estrogen re-
ceptor subtypes, ERa and ERß, prevent aldosterone-induced oxidative
stress in VSMC via increased NADPH bioavailability. Biochem Biophys Res
Commun. 2012; 423(4):850-6.
15. Zhang X, Liu J, Pang X, Zhao J, Wang S, Wu D. Aldosterone induces C-re-
active protein expression via MR-ROS-MAPK-NF-?B signal pathway in rat
vascular smooth muscle cells. Mol Cell Endocrinol. 2014; 395(1-2):61-
8.
16. Nagata D, Takahashi M, Sawai K, Tagami T, Usui T, Shimatsu A, Hirata
Y, Naruse M. Molecular mechanism of the inhibitory effect of aldosterone
on endothelial NO synthase activity. Hypertension. 2006; 48(1):165-71.
vascular endothelial cell function. J Cardiovasc Pharmacol. 2006;
47(4):609-13.
18. Iwashima F, Yoshimoto T, Minami I, Sakurada M, Hirono Y, Hirata Y. Al-
dosterone induces superoxide generation via Rac1 activation in endothelial
cells. Endocrinology. 2008; 149(3):1009-14.
19. Wilkinson-Berka JL, Tan G, Jaworski K, Miller AG. Identification of a retinal
aldosterone system and the protective effects of mineralocorticoid receptor
antagonism on retinal vascular pathology. Circ Res. 2009; 104(1):124-
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