Page 51 - 84_01
P. 51

Stem cells and their exosomes as an advanced therapy to treat incisional hernia: proof of concept in a murine model

29. Wassenaar E, Schoenmaeckers E, Raymakers J, et al.               Mesenchymal stem cells-derived exosomes are more
     Mesh-fixation method and pain and quality of life               immunosuppressive than microparticles in
     after laparoscopic ventral or incisional hernia repair: a       inflammatory arthritis. Theranostics 2018; 8(5): 1399–
     randomized trial of three fixation techniques. Surg             410.
     Endosc 2010; 24(6): 1296–302.
                                                                43. Di Trapani M, Bassi G, Midolo M, et al. Differential
30. Chatzimavroudis G, Kalaitzis S, Voloudakis N, et al.             and transferable modulatory effects of mesenchymal
     Evaluation of four mesh fixation methods in an                  stromal cell-derived extracellular vesicles on T, B and
     experimental model of ventral hernia repair. J Surg             NK cell functions. Sci Rep 2016; 6: 24120.
     Res 2017; 212: 253–9.
                                                                44. Wrammert J, Källberg E, Agace WW, Leanderson T.
31. Berninger MT, Wexel G, Rummeny EJ, et al.                        Ly6C expression differentiates plasma cells from
     Treatment of osteochondral defects in the rabbit’s              other B cell subsets in mice. Eur J Immunol 2002;
     knee joint by implantation of allogeneic mesenchymal            32(1): 97–103.
     stem cells in fibrin clots. J Vis Exp 2013; (75): e4423.
                                                                45. Abumaree MH, Al Jumah MA, Kalionis B, et al.
32. Ho W, Tawil B, Dunn JCY, Wu BM. The behavior of                  Human placental mesenchymal stem cells (pMSCs)
     human mesenchymal stem cells in 3D fibrin clots:                play a role as immune suppressive cells by shifting
     dependence on fibrinogen concentration and clot                 macrophage differentiation from inflammatory M1 to
     structure. Tissue Eng 2006; 12(6): 1587–95.                     anti-inflammatory M2 macrophages. Stem Cell Rev
                                                                     2013; 9(5): 620–41.
33. Blazquez R, Sanchez-Margallo FM, de la Rosa O,
     Dalemans W, et al. Immunomodulatory Potential of           46. Sica A, Mantovani A. Macrophage plasticity and
     Human Adipose Mesenchymal Stem Cells Derived                    polarization: in vivo veritas. J Clin Invest 2012;
     Exosomes on in vitro Stimulated T Cells. Front                  122(3): 787–95.
     Immunol 2014; 5: 556.
                                                                47. Rittling SR. Osteopontin in macrophage function.
34. G Casado J, Blázquez Durán R, Vela FJ, et al.                    Expert Rev Mol Med 2011; 13: e15.
     Mesenchymal stem cells derived exosomes:
     immunomodulatory evaluation in an antigen-induced          48. Henriksen NA, Yadete DH, Sorensen LT, et al.
     synovitis porcine model. Front Vet Sci 2017; 4: 39.             Connective tissue alteration in abdominal wall hernia.
                                                                     Br J Surg 2011; 98(2): 210–9.
35. Wolberg AS. Determinants of fibrin formation,
     structure, and function. Curr Opin Hematol 2012;
     19(5): 349–56.

36. Laurens N, Koolwijk P, de Maat MPM. Fibrin
     structure and wound healing. J Thromb Haemost
     2006; 4(5): 932–9.

37. Topart P, Vandenbroucke F, Lozac’h P. Tisseel versus
     tack staples as mesh fixation in totally extraperitoneal
     laparoscopic repair of groin hernias: a retrospective
     analysis. Surg Endosc 2005; 19(5): 724–7.

38. Katkhouda N, Mavor E, Friedlander MH, et al. Use of
     fibrin sealant for prosthetic mesh fixation in
     laparoscopic extraperitoneal inguinal hernia repair.
     Ann Surg 2001; 233(1): 18–25.

39. Zogbi L. The Use of Biomaterials to Treat Abdominal
     Hernias. En: Pignatello R, Ed. Biomaterials
     Applications for Nanomedicine (Internet). InTech
     2011 (2017 Sep 23). Disponible en
     (http://www.intechopen.com/books/biomaterials-
     applications-for-nanomedicine/the-use-of-
     biomaterials-to-treat-abdominal-hernias).

40. Lo Sicco C, Reverberi D, Balbi C, et al. Mesenchymal
     Stem Cell-Derived Extracellular Vesicles as
     Mediators of Anti-Inflammatory Effects: Endorsement
     of Macrophage Polarization. Stem Cells Transl Med
     2017; 6(3): 1018–28.

41. Suzuki E, Fujita D, Takahashi M, et al. Stem cell-
     derived exosomes as a therapeutic tool for
     cardiovascular disease. World J Stem Cells 2016;
     8(9): 297–305.

42. Cosenza S, Toupet K, Maumus M, et al.

@Real Academia Nacional de Farmacia. Spain                                                                           51
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