Page 34 - 84_01
P. 34
The nucleotide vesicular transporter (VNUT). Relevance in neural and neuroendocrine tissues. New pharmacological perspectives
parameters for the vesicular acetylcholine transporter: 51. Miras-Portugal MT, Torres M, Rotllan P, et al.
two protons are exchanged for one acetylcholine. Adenosine transport in bovine chromaffin cells in
Biochemistry 1998; 37: 13400-10. culture. J Biol Chem 1986; 261: 1712-9.
38. Juge N, Gray JA, Omote H, et al. Metabolic control of 52. Gunther Sillero MA, de Diego A, Silles E, et al.
vesicular glutamate transport and release. Neuron Synthesis of (di)nucleoside polyphosphates by the
2010; 68: 99-112. ubiquitin activating enzyme E1. FEBS Lett 2005; 579:
6223-9.
39. Alfonso A, Grundahl K, Duerr JS, et al. The
Caenorhabditis elegans unc-17 gene: a putative 53. Sillero MA, Guranowski A, Sillero A. Synthesis of
vesicular acetylcholine transporter. Science 1993; 261: dinucleoside polyphosphates catalyzed by firefly
617-9. luciferase. Eur J Biochem 1991; 202: 507-13.
40. Wojcik SM, Katsurabayashi S, Guillemin I, et al. A 54. Brevet A, Chen J, Leveque F, et al. In vivo synthesis
shared vesicular carrier allows synaptic corelease of of adenylylated bis(5'-nucleosidyl) tetraphosphates
GABA and glycine. Neuron 2006; 50: 575-87. (Ap4N) by Escherichia coli aminoacyl-tRNA
synthetases. Proc Natl Acad Sci U S A 1989; 86:
41. Gras C, Herzog E, Bellenchi GC, et al. A third 8275-9.
vesicular glutamate transporter expressed by
cholinergic and serotoninergic neurons. J Neurosci 55. Zamecnik PC, Stephenson ML, Janeway CM, et al.
2002; 22: 5442-51. Enzymatic synthesis of diadenosine tetraphosphate
and diadenosine triphosphate with a purified lysyl-
42. Farnsworth SJ, Volz TJ, Hanson GR, et al. Cocaine sRNA synthetase. Biochem Biophys Res Commun
alters vesicular dopamine sequestration and 1966; 24: 91-7.
potassium-stimulated dopamine release: the role of D2
receptor activation. J Pharmacol Exp Ther 2009; 328: 56. Jankowski V, van der Giet M, Mischak H, et al.
807-12. Dinucleoside polyphosphates: strong endogenous
agonists of the purinergic system. Br J Pharmacol
43. Volz TJ, Fleckenstein AE, Hanson GR. 2009; 157: 1142-53.
Methamphetamine-induced alterations in monoamine
transport: implications for neurotoxicity, 57. Pintor J, Diaz-Hernandez M, Gualix J, et al.
neuroprotection and treatment. Addiction 2007; 102 Diadenosine polyphosphate receptors. from rat and
Suppl 1: 44-8. guinea-pig brain to human nervous system. Pharmacol
Ther 2000; 87: 103-15.
44. Winter S, Brunk I, Walther DJ, et al. Galphao2
regulates vesicular glutamate transporter activity by 58. Pintor J, Rotllan P, Torres M, et al. Characterization
changing its chloride dependence. J Neurosci 2005; and quantification of diadenosine hexaphosphate in
25: 4672-80. chromaffin cells: granular storage and secretagogue-
induced release. Anal Biochem 1992; 200: 296-300.
45. Holtje M, Winter S, Walther D, et al. The vesicular
monoamine content regulates VMAT2 activity 59. Rodriguez del Castillo A, Torres M, Delicado EG, et
through Galphaq in mouse platelets. Evidence for al. Subcellular distribution studies of diadenosine
autoregulation of vesicular transmitter uptake. J Biol polyphosphates--Ap4A and Ap5A--in bovine adrenal
Chem 2003; 278: 15850-8. medulla: presence in chromaffin granules. J
Neurochem 1988; 51: 1696-703.
46. Ahnert-Hilger G, Nurnberg B, Exner T, et al. The
heterotrimeric G protein Go2 regulates catecholamine 60. Winkler H. The composition of adrenal chromaffin
uptake by secretory vesicles. EMBO J 1998; 17: 406- granules: an assessment of controversial results.
13. Neuroscience 1976; 1: 65-80.
47. Brunk I, Blex C, Rachakonda S, et al. The first 61. Pintor J, Torres M, Miras-Portugal MT. Carbachol
luminal domain of vesicular monoamine transporters induced release of diadenosine polyphosphates--Ap4A
mediates G-protein-dependent regulation of and Ap5A--from perfused bovine adrenal medulla and
transmitter uptake. J Biol Chem 2006; 281: 33373-85. isolated chromaffin cells. Life Sci 1991; 48: 2317-24.
48. Burnstock G, Kennedy C. P2X receptors in health and 62. Jo YH, Schlichter R. Synaptic corelease of ATP and
disease. Adv Pharmacol 2011; 61: 333-72. GABA in cultured spinal neurons. Nat Neurosci 1999;
2: 241-5.
49. Abbracchio MP, Burnstock G, Boeynaems JM, et al.
International Union of Pharmacology LVIII: update 63. Sawynok J, Downie JW, Reid AR, et al. ATP release
on the P2Y G protein-coupled nucleotide receptors: from dorsal spinal cord synaptosomes:
from molecular mechanisms and pathophysiology to characterization and neuronal origin. Brain Res 1993;
therapy. Pharmacol Rev 2006; 58: 281-341. 610: 32-8.
50. Gomez-Villafuertes R, Pintor J, Miras-Portugal MT, 64. von Kugelgen I, Starke K. Release of noradrenaline
et al. Ectonucleotide and ATP by electrical stimulation and nicotine in
pyrophosphatase/phosphodiesterase activity in Neuro- guinea-pig vas deferens. Naunyn Schmiedebergs Arch
2a neuroblastoma cells: changes in expression Pharmacol 1991; 344: 419-29.
associated with neuronal differentiation. J Neurochem
2014; 131: 290-302. 65. Richardson PJ, Brown SJ. ATP release from affinity-
@Real Academia Nacional de Farmacia. Spain 35
