Page 83 - 80_03
P. 83
A.Toledano
&
al.
51.
Cohen,
A.
D.;
Rabinovici,
G.
D.;
Mathis,
C.
A.;
Jagust,
W.
J.;
Klunk,
W.
E.;
Ikonomovic,
M.
D.
Using
Pittsburgh
Compound
B
for
in
vivo
PET
imaging
of
fibrillar
amyloid--beta.
Adv
Pharmacol
64,
27--81
(2012).
52.
Armstrong,
R.
A.
The
interface
between
Alzheimer's
disease,
normal
aging,
and
related
disorders.
Curr
Aging
Sci
1,
122--132
(2008).
53.
Saunders,
A.
M.;
Strittmatter,
W.
J.;
Schmechel,
D.;
George--Hyslop,
P.
H.;
Pericak--Vance,
M.
A.;
Joo,
S.
H.;
Rosi,
B.
L.;
Gusella,
J.
F.;
Crapper--MacLachlan,
D.
R.;
Alberts,
M.
J.
Association
of
apolipoprotein
E
allele
epsilon
4
with
late--onset
familial
and
sporadic
Alzheimer's
disease.
Neurology
43,
1467--1472
(1993).
54.
Ringman,
J.
M.;
Coppola,
G.
New
genes
and
new
insights
from
old
genes:
update
on
Alzheimer
disease.
Continuum
(Minneap
Minn)
19,
358--71
(2013).
55.
Serrano--Pozo,
A.;
Qian,
J.;
Monsell,
S.
E.;
Frosch,
M.
P.;
Betensky,
R.A.;
Hyman,
B.
T.
Examination
of
the
clinicopathologic
continuum
of
Alzheimer
disease
in
the
autopsy
cohort
of
the
National
Alzheimer
Coordinating
Center.
J
Neuropathol
Exp
Neurol.
72,1182--
1192
(2013).
56.
Pappolla,
M.
A.
La
Neuropatología
y
la
Biología
Molecular
de
la
Enfermedad
de
Alzheimer.
En:.
Neuropathología.
Diagnóstico
y
Clínica.
Cruz--Sánchez
F.F.,
Ed.;
Edimsa,
Barcelona,
2000;
p
543.
57.
Penke,
B.;
Tóth,
A.
M.;
Földi,
I.;
Szucs,
M.;
Janáky,
T.
Intraneuronal
ß--amyloid
and
its
interactions
with
proteins
and
subcellular
organelles.
Electrophoresis
33,
3608--3616
(2012).
58.
Delacourte,
A.
General
and
dramatic
glial
reaction
in
Alzheimer
brains.
Neurology
40,
33--
37
(1990)
59.
Dickson;
C.,
Vickers,
J.
C.
The
morphological
phenotype
of
b--amyloid
plaques
and
associated
neuritic
changes
in
Alzheimer's.
Neuroscience
105,
99--107
(2001).
60.
Wegiel,
J.;
Wang,
K.
C.;
Tarnawski,
M.;
Lach,
B.
Microglia
cells
are
the
driving
force
in
fibrillar
plaque
formation,
whereas
astrocytes
are
a
leading
factor
in
plague
degradation.
Acta
Neuropathol
100,
356–364
(2000).
61.
Bartus,
R.
T.;
Dean,
R.
L.;
3rd,
Beer,
B.
Lippa
AS
The
cholinergic
hypothesis
of
geriatric
memory
dysfunction.
Science
30,
217(4558):408--14
(1982).
62.
Mann,
D.
M.;
Yates,
P.
O.;
Marcyniuk,
B.
Alzheimer's
presenile
dementia,
senile
dementia
of
Alzheimer
type
and
Down's
syndrome
in
middle
age
form
an
age
related
continuum
of
pathological
changes.
Neuropathol
Appl
Neurobiol
10,
185--207
(1984).
63.
Mecocci,
P.
Oxidative
stress
in
mild
cognitive
impairment
and
Alzheimer
disease:
a
continuum.
J
Alzheimers
Dis.
2004
Apr;6(2):159--63.
64.
Nixon,
R.
A.;
Yang,
D.
S.;
Lee,
J.
H.
Neurodegenerative
lysosomal
disorders:
a
continuum
from
development
to
late
age.
Autophagy
4,
590--9
(2008).
65.
Toledano,
A.;
Álvarez,
MI.;
Rivas,
L.;
Lacruz,
C.;
Martínez--Rodríguez,
R.
Amyloid
precursor
protein
in
the
cerebellar
cortex
of
Alzheimer
's
disease
patients
devoid
of
cerebellar
ß--
amyloid
deposits.
Immunocytochemical
study
of
five
cases.
J
Neural
Trans
106,
1151--
1169
(1999).
66.
Toledano,
A.
Hypotheses
concerning
the
aetiology
of
the
Alzheimer's
disease.
Pharmacopsychiat
21,
17--25
(1988).
67.
Toledano,
A.;
Bentura,
M.
Pyritinol
facilitates
the
recovery
of
cortical
cholinergic
deficits
caused
by
nucleus
basalis
lesions
J
Neural
Transm
[P--D
Section]
7,
195--209
(1994).
68.
Drachman,
D.
A.;
Leavitt,
J.
Human
memory
and
the
cholinergic
system:
relationship
to
aging?
Arch
Neurol
30,
113–121
(1974).
69.
Coyle,
J.
T.;
Price,
D.
L.;
De
Long,
M.
R.
Alzheimer's
disease:
a
disorder
of
cortical
cholinergic
innervation.
Science
219,
1184--1190
(1983).
70.
Schneider,
L.
S.
Alzheimer
disease
pharmacologic
treatment
and
treatment
research.
Continuum
(Minneap
Minn).
19,
339--357
(2013).
71.
Van
Hoesen,
G.
W.;
Augustinack,
J.
C.;
Dierking,
J.;
Redman,
S.
J.;
Thangavel,
R.
The
parahippocampal
gyrus
in
Alzheimer's
disease.
Clinical
and
preclinical
neuroanatomical
correlates.
Ann
N
Y
Acad
Sci
911,
254--274
(2000).
72.
de
Toledo--Morrell,
L.;
Goncharova,
I.;
Dickerson,
B.;
Wilson,
R.
S.;
Bennett,
D.
A.
From
healthy
aging
to
early
Alzheimer's
disease:
in
vivo
detection
of
entorhinal
cortex
atrophy.
Ann
N
Y
Acad
Sci
911,
240--53
(2000).
73.
Stricker,
N.
H.;(1),
Chang,
Y.
L.;
Fennema--Notestine,
C.;
Delano--Wood,
L.;
Salmon,
D.
P.;
Bondi,
M.
W.;
Dale,
A.
M.
Alzheimer's
Disease
Neuroimaging
Initiative.
Distinct
profiles
of
536