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P. 107

Almudena	
  Gómez-­-Hernández	
  &	
  al.	
  

	
  

     86. Guerra	
   C,	
   Koza	
   RA,	
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   H,	
   Walsh	
   K,	
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   Emergence	
   of	
   brown	
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   in	
  
          white	
   fat	
   in	
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     87. Lowell	
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   J,	
   Boyer	
   BB,	
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   al.	
  
          Development	
  of	
  obesity	
  in	
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  mice	
  after	
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  ablation	
  of	
  brown	
  adipose	
  tissue.	
  
          Nature.	
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  366:740–2.	
  

     88. Guerra	
   C,	
   Navarro	
   P,	
   Valverde	
   AM,	
   Arribas	
   M,	
   Brüning	
   J,	
   Kozak	
   LP,	
   et	
   al.	
   Brown	
   adipose	
  
          tissue-­-specific	
   insulin	
   receptor	
   knockout	
   shows	
   diabetic	
   phenotype	
   without	
   insulin	
  
          resistance.	
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     89. Kontani	
  Y,	
  Wang	
  Y,	
  Kimura	
  K,	
  Inokuma	
  KI,	
  Saito	
  M,	
  Suzuki-­-Miura	
  T,	
  et	
  al.	
  UCP1	
  deficiency	
  
          increases	
  susceptibility	
  to	
  diet-­-induced	
  obesity	
  with	
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  Aging	
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     90. Cypess	
   AM,	
   Lehman	
   S,	
   Williams	
   G,	
   Tal	
   I,	
   Rodman	
   D,	
   Goldfine	
   AB,	
   et	
   al.	
   Identification	
   and	
  
          importance	
   of	
   brown	
   adipose	
   tissue	
   in	
   adult	
   humans.	
   N	
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   Med.	
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          17.	
  

     91. Hansen	
   JB,	
   Kristiansen	
   K.	
   Regulatory	
   circuits	
   controlling	
   white	
   versus	
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   adipocyte	
  
          differentiation.	
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     92. Cannon	
   B,	
   Nedergaard	
   J.	
   Brown	
   adipose	
   tissue:	
   function	
   and	
   physiological	
   significance.	
  
          Physiol	
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     93. Bartelt	
  A,	
  Bruns	
  OT,	
  Reimer	
  R,	
  Hohenberg	
  H,	
  Ittrich	
  H,	
  Peldschus	
  K,	
  et	
  al.	
  Brown	
  adipose	
  
          tissue	
  activity	
  controls	
  triglyceride	
  clearance.	
  Nat	
  Med.	
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     94. Williams	
   KJ.	
   Molecular	
   processes	
   that	
   handle	
   -­--­-	
   and	
   mishandle	
   -­--­-	
   dietary	
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   J	
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          Invest.	
  2008;	
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     95. Hokanson	
   JE,	
   Austin	
   MA.	
   Plasma	
   triglyceride	
   level	
   is	
   a	
   risk	
   factor	
   for	
   cardiovascular	
  
          disease	
   independent	
   of	
   high-­-density	
   lipoprotein	
   cholesterol	
   level:	
   a	
   meta-­-analysis	
   of	
  
          population-­-based	
  prospective	
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     96. Austin	
   MA,	
   McKnight	
   B,	
   Edwards	
   KL,	
   Bradley	
   CM,	
   McNeely	
   MJ,	
   Psaty	
   BM,	
   et	
   al.	
  
          Cardiovascular	
   disease	
   mortality	
   in	
   familial	
   forms	
   of	
   hypertriglyceridemia:	
   A	
   20-­-year	
  
          prospective	
  study.	
  Circulation.	
  2000;	
  101(24):2777-­-82.	
  

     97. Mooradian	
  AD.	
  Dyslipidemia	
  in	
  type	
  2	
  diabetes	
  mellitus.	
  Nat	
  Clin	
  Pract	
  Endocrinol	
  Metab.	
  
          2009;	
  5(3):150-­-9.	
  

     98. Fredriksson	
   JM,	
   Nikami	
   H,	
   Nedergaard	
   J.	
   Cold-­-induced	
   expression	
   of	
   the	
   VEGF	
   gene	
   in	
  
          brown	
   adipose	
   tissue	
   is	
   independent	
   of	
   thermogenic	
   oxygen	
   consumption.	
   FEBS	
   Lett.	
  
          2005;	
  579(25):5680-­-4.	
  

     99. Mitchell	
  JR,	
  Jacobsson	
  A,	
  Kirchgessner	
  TG,	
  Schotz	
  MC,	
  Cannon	
  B,	
  Nedergaard	
  J.	
  Regulation	
  
          of	
   expression	
   of	
   the	
   lipoprotein	
   lipase	
   gene	
   in	
   brown	
   adipose	
   tissue.	
   Am	
   J	
   Physiol.	
   1992;	
  
          263(3	
  Pt	
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     100. Ouellet	
   V,	
   Labbé	
   SM,	
   Blondin	
   DP,	
   Phoenix	
   S,	
   Guérin	
   B,	
   Haman	
   F,	
   et	
   al.	
   Brown	
  
          adipose	
   tissue	
   oxidative	
   metabolism	
   contributes	
   to	
   energy	
   expenditure	
   during	
   acute	
   cold	
  
          exposure	
  in	
  humans.	
  J	
  Clin	
  Invest.	
  2012;	
  122(2):545-­-52.	
  	
  

     101. Chechi	
   K,	
   Blanchard	
   PG,	
   Mathieu	
   P,	
   Deshaies	
   Y,	
   Richard	
   D.	
   Brown	
   fat	
   like	
   gene	
  
          expression	
   in	
   the	
   epicardial	
   fat	
   depot	
   correlates	
   with	
   circulating	
   HDL-­-cholesterol	
   and	
  
          triglycerides	
  in	
  patients	
  with	
  coronary	
  artery	
  disease.	
  Int	
  J	
  Cardiol.	
  2012	
  Jun	
  22.	
  

     102. Shabalina	
   IG,	
   Jacobsson	
   A,	
   Cannon	
   B,	
   Nedergaard	
   J.	
   Native	
   UCP1	
   displays	
   simple	
  
          competitive	
   kinetics	
   between	
   the	
   regulators	
   purine	
   nucleotides	
   and	
   fatty	
   acids.	
   J	
   Biol	
  
          Chem.	
  2004;	
  279(37):38236-­-48.	
  	
  

     103. Nikami	
  H,	
  Shimizu	
  Y,	
  Endoh	
  D,	
  Yano	
  H,	
  Saito	
  M.	
  Cold	
  exposure	
  increases	
  glucose	
  
          utilization	
   and	
   glucose	
   transporter	
   expression	
   in	
   brown	
   adipose	
   tissue.	
   Biochem	
   Biophys	
  
          Res	
  Commun.	
  1992;	
  185(3):1078-­-82	
  

     104. Dallner	
   OS,	
   Chernogubova	
   E,	
   Brolinson	
   KA,	
   Bengtsson	
   T.	
   Beta3-­-adrenergic	
  
          receptors	
   stimulate	
   glucose	
   uptake	
   in	
   brown	
   adipocytes	
   by	
   two	
   mechanisms	
  
          independently	
   of	
   glucose	
   transporter	
   4	
   translocation.	
   Endocrinology.	
   2006;	
  
          147(12):5730-­-9.	
  

     105. Chartoumpekis	
   DV,	
   Habeos	
   IG,	
   Ziros	
   PG,	
   Psyrogiannis	
   AI,	
   Kyriazopoulou	
   VE,	
  
          Papavassiliou	
   AG.	
   Brown	
   adipose	
   tissue	
   responds	
   to	
   cold	
   and	
   adrenergic	
   stimulation	
   by	
  
          induction	
  of	
  FGF21.	
  Mol	
  Med.	
  2011;	
  17(7-­-8):736-­-40.	
  	
  

     106. Hondares	
   E,	
   Iglesias	
   R,	
   Giralt	
   A,	
   Gonzalez	
   FJ,	
   Giralt	
   M,	
   Mampel	
   T,	
   et	
   al.	
  
          Thermogenic	
   activation	
   induces	
   FGF21	
   expression	
   and	
   release	
   in	
   brown	
   adipose	
   tissue.	
   J	
  
          Biol	
  Chem.	
  2011;	
  286(15):12983-­-90.	
  	
  

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