Page 106 - 80_02

Papel
del
tejido
adiposo
blanco,
marrón
y
perivascular…

62. Hube
F,
Birgel
M,
Lee
YM,
Hauner
H.
Expression
pattern
of
tumour
necrosis
factor

receptors
in
subcutaneous
and
omental
human
adipose
tissue:
role
of
obesity
and

noninsulin-­-dependent
diabetes
mellitus.
Eur
J
Clin
Invest
1999;
29(8):672–678.

63. Ruan
H,
Lodish
HF.
Insulin
resistance
in
adipose
tissue:
direct
and
indirect
effects
of
tumor

necrosis
factor-­-alpha.
Cytokine
Growth
Factor
Rev.
2003;
14(5):447–455

64. Uysal
KT,
Wiesbrock
SM,
MarinoMW,
Hotamisligil
GS.
Protection
from
obesity-­-induced

insulin
resistance
in
mice
lacking
TNF-­-alpha
function.
Nature
1997;
389:610–614

65. Takano
M,
Nishihara
R,
Sugano
N,
Matsumoto
K,
Yamada
Y,
Takane
M,
et
al.
The
effect
of

systemic
anti-­-tumor
necrosis
factor-­-alpha
treatment
on
Porphyromonas
gingivalis

infection
in
type
2
diabetic
mice.
Arch
Oral
Biol.
2010;
55(5):379–384

66. Gómez-­-Hernández
A,
Otero
YF,
de
las
Heras
N,
Escribano
O,
Cachofeiro
V,
Lahera
V,
et
al.

Brown
fat
lipoatrophy
and
increased
visceral
adiposity
through
a
concerted

adipocytokines
overexpression
induces
vascular
insulin
resistance
and
dysfunction.

Endocrinology.
2012;
153(3):1242-­-55.

67. Van
Harmelen
V,
Ariapart
P,
Hoffstedt
J,
Lundkvist
I,
Bringman
S,
Arner
P.
Increased

adipose
angiotensinogen
gene
expression
in
human
obesity.
Obes
Res.
2000;
8(4):337-­-41.

68. Shimomura
I,
Funahashi
T,
Takahashi
M,
Maeda
K,
Kotani
K,
Nakamura
T
et
al.
Enhanced

expression
of
PAI-­-1
in
visceral
fat:
possible
contributor
to
vascular
disease
in
obesity.
Nat

Med.
1996;
2(7):800-­-3.

69. Jones
BH,
Standridge
MK,
Moustaid
N.
Angiotensin
II
increases
lipogenesis
in
3T3-­-L1
and

human
adipose
cells.
Endocrinology.
1997;
138(4):1512-­-9.

70. Gil
A,
María
Aguilera
C,
Gil-­-Campos
M,
Cañete
R.
Altered
signalling
and
gene
expression

associated
with
the
immune
system
and
the
inflammatory
response
in
obesity.
Br
J
Nutr.

2007;
98
Suppl
1:S121-­-6.

71. Baker
RG,
Hayden
MS,
Ghosh
S.
NF-­-?B,
inflammation,
and
metabolic
disease.
Cell
Metab.

2011;
13(1):11-­-22.

72. Chawla
A,
Nguyen
KD,
Goh
YP.
Macrophage-­-mediated
inflammation
in
metabolic
disease.

Nat
Rev
Immunol.
2011;
11(11):738-­-49.

73. Nishimura
S,
Manabe
I,
Nagasaki
M,
Eto
K,
Yamashita
H,
Ohsugi
M
et
al.
CD8+
effector
T

cells
contribute
to
macrophage
recruitment
and
adipose
tissue
inflammation
in
obesity.

Nat
Med
2009;
15(8):914–920.

74. Crandall
DL,
Hausman
GJ,
Kral
JG.
A
review
of
the
microcirculation
of
adipose
tissue:

anatomic,
metabolic,
and
angiogenic
perspectives.
Microcirculation.
1997;
4(2):211-­-32.

75. Blake
GJ,
Ridker
PM.
Inflammatory
bio-­-markers
and
cardiovascular
risk
prediction.
J

Intern
Med.
2002;
252(4):283-­-94.

76. Sengenès
C,
Miranville
A,
Lolmède
K,
Curat
CA,
Bouloumié
A.
The
role
of
endothelial
cells

in
inflamed
adipose
tissue.
J
Intern
Med.
2007;
262(4):415-­-21

77. Cai
D,
Yuan
M,
Frantz
DF,
Melendez
PA,
Hansen
L,
Lee
J,
et
al.
Local
and
systemic
insulin

resistance
resulting
from
hepatic
activation
of
IKK-­-beta
and
NF-­-kappaB.
Nat
Med.
2005;

11(2):183-­-90.

78. Racanelli
V,
Rehermann
B.
The
liver
as
an
immunological
organ.
Hepatology.
2006;
43(2

Suppl
1):S54-­-62.

79. Shoelson
SE,
Lee
J,
Goldfine
AB.
Inflammation
and
insulin
resistance.
J
Clin
Invest.
2006;

116(7):1793-­-801.

80. Mattson
MP.
Perspective:
Does
brown
fat
protect
against
diseases
of
aging?
Ageing
Res

Rev.
2010;
9(1):69-­-76.

81. Farmer
SR.
Transcriptional
control
of
adipocyte
formation.
Cell
Metab.
2006;
4
(4):263–
73.

82. Ishibashi
J,
Seale
P.
Medicine.
Beige
can
be
slimming.
Science.
2010;
328(5982):1113-­-4.

83. Wu
J,
Boström
P,
Sparks
LM,
Ye
L,
Choi
JH,
Giang
AH,
et
al.
Beige
adipocytes
are
a
distinct

type
of
thermogenic
fat
cell
in
mouse
and
human.
Cell.
2012;
150(2):366-­-76.

84. Boström
P,
Wu
J,
Jedrychowski
MP,
Korde
A,
Ye
L,
Lo
JC,
et
al.
A
PGC1-­-a-­-dependent

myokine
that
drives
brown-­-fat-­-like
development
of
white
fat
and
thermogenesis.
Nature.

2012;
481(7382):463-­-8.

85. Ghorbani
M,
Claus
TH,
Himms-­-Hagen
J.
Hypertrophy
of
brown
adipocytes
in
brown
and

white
adipose
tissues
and
reversal
of
diet-­-induced
obesity
in
rats
treated
with
a
beta3-­-
adrenoceptor
agonist.
Biochem
Pharmacol.
1997;
54(1):121-­-31.

343