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C.
Hernández-­-Sánchez,
P.
Vázquez,
Flora
de
Pablo

demostrado
efectos
directos
de
la
dopamina
sobre
la
expresión
de
genes

cardiacos
y
hemos
avanzado
en
caracterizar
una
función
de
las
catecolaminas

sobre
la
formación
del
patrón
del
corazón.

Palabras
clave:
tirosina
hidroxilasa;
catecolaminas;
dopamina;
cardiogénesis.

1.
INTRODUCTION

Hormones
and
neurotransmitters
synthesis
localized,
under
traditional

views,
within
the
endocrine
and
nervous
systems,
respectively.
In
contrast,
others

and
we
have
found
expression
of
hormones
much
earlier
in
development
than
the

emergence
of
the
endocrine
gland
especialized
in
their
secretion
takes
place.
For

example,
growth
hormone,
secreted
in
adult
organisms
by
the
pituitary
gland,
is

detected
in
the
blastocyst
and
many
extrapituitary
tissues
during
development
(1).

Figure
1.
The
catecholamine
biosynthesis
pathway.
Note
that
TH
is
the
rate-­-limiting
enzyme

and
that
in
developing
tissues
the
pathway
may
not
lead
to
the
production
of
all
three

catecholamines.

348