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C.	
  Martín	
  y	
  A.	
  I.	
  Torres	
                                                                                                                       	
  

	
  

     27. Luo,	
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  Gu,	
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  Erlotinib	
  inhibits	
  T-­-cell-­-mediated	
  immune	
  response	
  
          via	
   down-­-regulation	
   of	
   the	
   c-­-Raf/ERK	
   cascade	
   and	
   Akt	
   signaling	
   pathway.	
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          Pharmacol	
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     28. Duffour,	
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   Inter-­-observer	
   agreement	
   between	
  
          dermatologists	
   and	
   oncologists	
   in	
   assessing	
   dermatological	
   toxicities	
   in	
   patients	
   with	
  
          metastatic	
   colorectal	
   cancer	
   treated	
   by	
   cetuximab-­-based	
   chemotherapies:	
   A	
   pilot	
  
          comparative	
  study.	
  Eur	
  J	
  Cancer	
  46,	
  3169-­-3174.	
  

     29. Dinh,	
   P.;	
   Harnett,	
   P.;	
   Piccart-­-Gebhart,	
   MJ.;	
   Awada,	
   A.	
   (2008)	
   New	
   therapies	
   for	
   ovarian	
  
          cancer:	
  Cytotoxics	
  and	
  molecularly	
  targeted	
  agents.	
  Crit	
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     30. Seiden	
   MV,	
   Burris	
   HA,	
   Matulonis	
   U,	
   et	
   al.	
   A	
   phase	
   II	
   trial	
   of	
   EMD72000	
   (matuzumab),	
   a	
  
          humanized	
   anti-­-EGFR	
   monoclonal	
   antibody,	
   in	
   patients	
   with	
   platinum-­-resistant	
   ovarian	
  
          and	
  primary	
  peritoneal	
  malignancies.	
  Gynecol	
  Oncol	
  104,	
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     31. Ismael.	
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   Dornelles.	
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   Mano,	
   MS.;	
   Awada.	
   A.	
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   drugs:	
   Old	
  
          challenges,	
  new	
  solutions.	
  Cancer	
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     32. Hotta,	
   K.;	
   Ueok,	
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   New	
   cytotoxic	
   agents:	
   a	
   review	
   of	
   the	
   literature.	
   Crit	
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          Oncol/hematol	
  55,	
  45-­-65.	
  

     33. Natsume,	
   T.;	
   Watanabe,	
   J.;	
   Koh,	
   Y.	
   et	
   al.	
   (2003)	
   Antitumor	
   activity	
   of	
   TZT-­-1027	
  
          (soblidotin)	
   against	
   vascular	
   endothelial	
   growth	
   factor	
   secreting	
   human	
   lung	
   cancer	
   in	
  
          vivo.	
  Cancer	
  Sci	
  94,	
  826-­-833.	
  

     34. Natsume	
  T,	
  Watanabe	
  J,	
  Koh	
  Y,	
  et	
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  (2003)	
  Antitumor	
  activity	
  of	
  TZT-­-1027	
  (Soblidotin)	
  
          against	
   vascular	
   endothelial	
   growth	
   factor-­-secreting	
   human	
   lung	
   cancer	
   in	
   vivo.	
   Cancer	
  
          Sci	
  94,	
  826-­-	
  833.	
  

     35. Riely,	
  GJ.;	
  Gadgeel,	
  S.;	
  Rothman,	
  I.;	
  Saidman,	
  B.;	
  Sabbath,	
  K.;	
  Feit,	
  K.	
  (2007)	
  A	
  phase	
  2	
  study	
  
          of	
   TZT-­-1027,	
   administered	
   weekly	
   to	
   patients	
   with	
   advanced	
   non-­-small	
   cell	
   lung	
   cancer	
  
          following	
  treatment	
  with	
  platinum-­-based	
  chemotherapy.	
  Lung	
  Cancer	
  55,	
  181-­-185.	
  

     36. Kamsteeg,	
   M.;	
   Rutherford,	
   T.;	
   Sapi,	
   E.;	
   et	
   al.	
   (2003)	
   Phenoxodiol	
   –an	
   isoflavone	
   analog–	
  
          induces	
  apoptosis	
  in	
  chemoresistant	
  ovarian	
  cancer	
  cells.	
  Oncogene	
  22(17),	
  2611-­-2620.	
  

     37. Aguero,	
   MF.;	
   Facchinetti,	
   MM.;	
   Sheleg,	
   Z.;	
   Senderowicz,	
   AM.	
   (2005)	
   Phenoxodiol,	
   a	
   novel	
  
          isoflavone,	
  induces	
  G1	
  arrest	
  by	
  specific	
  loss	
  in	
  cyclin-­-dependent	
  kinase	
  2	
  activity	
  by	
  p53-­-	
  
          independent	
  induction	
  of	
  p21WAF1/CIP1.	
  Cancer	
  Res	
  65(8),	
  3364-­-3373.	
  

     38. Tonary,	
   AM.;	
   Macdonald,	
   EA.;	
   Faught,	
   W.	
   et	
   al.	
   (2000)	
   Lack	
   of	
   expression	
   of	
   c-­-Kit	
   in	
  
          ovarian	
  cancers	
  is	
  associated	
  with	
  poor	
  prognosis.	
  Int	
  J	
  Cancer	
  89(3),	
  242-­-250.	
  

     39. Reynoso,	
  D.;	
  Nolden,	
  LK.;	
  Yang,	
  D.;	
  et	
  al.	
  (2011)	
  Synergistic	
  induction	
  of	
  apoptosis	
  by	
  the	
  
          Bcl-­-2	
   inhibitor	
   ABT-­-737	
   and	
   imatinib	
   mesylate	
   in	
   gastrointestinal	
   stromal	
   tumor	
   cells.	
  
          Mol	
  Oncol	
  5,	
  93-­-104.	
  

	
  

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