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ARTÍCULO'

Silencing( Beta2-Adrenergic( Receptors( Reduces( Intraocular(
Pressure:(A(New(Approach(for(Glaucoma(Therapy((

Jesús(Pintor(

Departamento! de! Bioquímica! y! Biología! Molecular.! Escuela! de! Óptica.! Universidad! Complutense.!
28037!Madrid.!Spain.!
Trabajo' premiado' con' el' Premio' de' la' Real' Academia' Nacional' de' Farmacia' de' su' Concurso' Científico'
2011.'
e?mail:'jpintor@vet.ucm.es'

ABSTRACT(
The( search( for( new( treatments( for( ocular( hypertension( and( glaucoma,( due( to( the(
side(effects(commercial(products(present,(is(inviting(to(look(for(new(strategies(apart(
from( the( available( ones.( In( this( sense( the( interference( RNA( technique( (RNAi),( also(
known( as( siRNA( to( selectively( silence( beta2( adrenergic( receptors( has( been(
investigated.( In( this( sense( it( has( been( obtained( a( reduction( in( intraocular( pressure(
(IOP),( the( main( factor( triggering( glaucoma,( of( 30( ±( 5( %,( compared( to( a( control(
(scrambled( siRNA).( The( results( were( in( terms( of( IOP( reduction( similar( to( that(
obtained( with( commercial( compounds( but( the( duration( of( the( siRNA( for( the( beta2(
adrenoceptor( lasted( for( almost( 5( days,( compared( to( the( average( of( 8( hours( in( the(
case( of( the( other( commercial( compounds.( No( apparent( side( effects( were( observed(
in(the(ocular(structures.(In(summary,(the(use(of(siRNA(against(the(beta2(adrenergic(
receptors(open(a(new(perspective(for(the(treatment(of(glaucoma.(

Keywords:!Glaucoma;!Intraocular!Pressure;!Adrenergic!Receptors;!siR.!

RESUMEN(
Los$ Receptores$ con$ Silenciador$ Beta23Adrenérgicos,$ reducen$ la$ presión$
intraocular:$Un$nuevo$acercamiento$a$la$terapia$del$Glaucoma$
La( búsqueda( de( nuevos( tratamientos( para( la( hipertensión( ocular( y( el( glaucoma,(
dado( los( efectos( secundarios( que( presentan( los( fármacos( actuales,( sugieren( el(
desarrollo( de( estrategias( diferentes( a( las( actualmente( disponibles.( En( este( sentido(
se( ha( puesto( a( punto( la( tecnología( de( los( RNA( de( interferencia( (RNAi)( también(
llamados( siRNA( para( silenciando( selectivamente( los( receptores( beta2( adrenérgicos(
tratar(de(obtener(una(reducción(sustancial(de(la(presión(intraocular((PIO),(principal(

230$

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