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5.(ACKNOWLEDGEMENTS(

This work was supported by grants from Ministerio de Ciencia e Innovación
[SAF2010-16024]; RETIC Red de Patología ocular del envejecimiento, calidad visual y
calidad de vida [RD07/0062/0004]; NEUROTRANS CM [S-SAL 0253-2006]; and
BSCHUCM [GR58/08].

6.(REFERENCES(

1.!Sears!M.,!&!Mead!A.!(1983).!A!major!pathway!for!the!regulation!of!intraocular!pressure.!Internat'
Ophthalmol!6,!201Y212.!
2.! Davson! H.! (1993).! The! aqueous! humour! and! the! intraocular! pressure.! In:! Davson! H! (ed).!
Physiology!of!the!eye.!Pergamon!Press:!New!York,!pp!34Y95.!
3.! Rohde! B.H.,! ! McLaughlin! M.A.,! &! Chiou! L.Y.! (1985)! Existence! and! role! of! endogenous! ocular!
melatonin.!J'Ocul'Pharmacol!1,!235–243.!
4.! Pintor! J.! (2009)! Autonomic! Nervous! System:! Ophthalmic! Control.! In:! Squire! LR! (ed.)!
Encyclopedia!of!Neuroscience.!Academic!Press:!Oxford,!pp.!967Y974.!
5.!Behlke!M.A.!(2006).!Progress!towards!in!vivo!use!of!siRNAs.!Mol'Ther!13,!644Y670.!
6.Y! Bumcrot! D.,! Manoharan! M.,! Koteliansky! V.,! &! Sah! D.W.! (2006).! RNAi! therapeutics:! a! potential!
new!class!of!pharmaceutical!drugs.!Nat'Chem'Biol.;2(12),711Y719.!
7.! Reich! S.J.! (2003).! Small! interfering! RNA! (siRNA)! targeting! VEGF! effectively! inhibits! ocular!
neovascularization!in!a!mouse!model.!Mol.'Vis.'9,!210Y216.!
8.! ! Tolentino! M.J.,! Brucker! A.J.,! Fosnot! J.,! Ying! G.S.,! Wu! I.H.,! Malik! G.,! Wan! S.,! ! &! Reich! S.J.! (2004)!
Intravitreal! injection! of! vascular! endothelial! growth! factor! small! interfering! RNA! inhibits! growth!
and! leakage! in! a! nonhuman! primate,! laserYinduced! model! of! choroidal! neovascularization.! Retina'
24(1),132Y138.!
9.! Macha! S.,! Mitra! A.K.,! &! Hughes,! P.M.! (2003).! Overview! of! ocular! drug! delivery.! In:! Ophthalmic!
drug!delivery!systems.!Ed.!A.K.!Mitra.!Pp!1Y12,!Marcel!Dekker!(USA).!
10.!Lee,!V.H.L.!(1990).!Mechanism!and!facilitation!of!corneal!drug!penetration.! J.'Control.'Rel.!11,!
79Y86.!
11.! Sugrue! M.F.! (2000).! Pharmacological! and! ocular! hypotensive! properties! of! topical! carbonic!
anhydrase!inhibitors.!Prog.'Ret.'Eye'Res.!19(1),!87Y112.!
12.! Pfeiffer! N.! (1997).! Dorzolamide:! Development! and! clinical! application! of! a! topical! carbonic!
anhydrase!inhibitor.!Survey'Ophthalmol.!42(2),!137Y151.!
13.! Jackson! A.L.! (2003).! Expression! profiling! reveals! offYtarget! gene! regulation! by! RNAi.! Nat.'
Biotechnol.!21(6),!635Y637.!
14.! Hornung! V.! (2005).! SequenceYspecific! potent! induction! of! IFNYalpha! by! short! interfering! RNA!
in!plasmacytoid!dendritic!cells!through!TLR7.!Nat.'Med.!11(3),!263Y70.!
15.! Fire! A.! (1998).! Potent! and! specific! genetic! interference! by! doubleYstranded! RNA! in!
Caenorhabditis'elegans.!Nature.!391(6669),!806Y811.!

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