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ÓSCAR ESCRIBANO Y COLS. AN. R. ACAD. NAC. FARM.

1 in transgenic mice: repercussions on reproduction, ante- and perinatal
mortality and postnatal growth. Endocrinology. 138: 2937-2947.
33. Rajkumar, K.; Barron, F.; Lewitt, M. S. & Murphy, L. J. (1995) Growth
retardation and hyperglycemia in insulin like growth factor binding protein-
1 transgenic mice. Endocrinology. 136, 4029-4034.
34. Rajkumar, K.; Dheen, S. T. & Murphy, L. J. (1996) Hyperglycemia and
impaired glucose tolerance in insulin-like growth factor binding protein-1
transgenic mice. Am. J. Physiol. 270: E565-E571.
35. Rajkumar, K.; Krsek, M.; Dheen, S. T. & Murphy, L. J. (1996) Impaired glucose
homeostasis in insulin-like growth factor binding protein-1 transgenic mice.
J. Clin. Invest. 98: 1818-1825.
36. Dheen, S. T.; Rajkumar, K. & Murphy, L. J. (1997) Islet cell proliferation and
apoptosis in insulin-like growth factor binding protein-1 in transgenic mice.
J. Endocrinol. 155: 551-558.
37. Denley, A.; Bonython, E. R.; Booker, G. W.; Cosgrove, L. J.; Forbes, B. E.;
Ward, C. W. & Wallace, J. C. (2004) Structural determinants for high-affinity
binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11
minus isoform of the IR. Mol. Endocrinol. 18: 2502-2512.

* Información de contacto:
Dr. Manuel Benito de las Heras.
Department of Biochemistry and Molecular Biology II. Faculty of Pharmacy.
Complutense University of Madrid, Spain.
Plaza Ramón y Cajal s/n. 28040 Madrid.
Telf.: +34 91 394 17 77. Fax: +34 91 394 17 79
Email: benito@farm.ucm.es

Abreviations: iLIRKO, Inducible Liver-specific IR KnockOut mouse. IGF-I,
Insulin-like Growth Factor type I. PEPCK, Phosphoenol pyruvate carboxykinase.
FAS, Fatty acid synthase. GK, Glucokinase. IR, Insulin Receptor. IR-A, insulin
receptor A isoform. IR-B, insulin receptor B isoform. BAT, brown adipose tissue.
WAT, white adipose tissue.

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