Page 119 - 76_01
P. 119
VOL. 76 (1), 23-44, 2010 BETA-CELL HYPERPLASIA INDUCED BY HEPATIC INSULIN...
20. Escribano, O.; Fernández-Moreno, M. D.; Zueco, J. A.; Menor, C.; Fueyo, J.;
Ropero, R. M.; Díaz-Laviada, I.; Román, I. D. & Guijarro, L. G. (2003) Insulin
receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating
rat liver. Hepatology. 37: 1461-1469.
21. Flier, S. N.; Kulkarni, R. N. & Kahn, C. R. (2001) Evidence for a circulating
islet cell growth factor in insulin-resistant status. Proc. Natl. Acad. Sci. USA.
98: 7475-7480.
22. McClain, D. A. (1991) Different ligand affinities of the two human IR splice
variants are reflected in parallel changes in sensitivity for insulin action. Mol.
Endocrinol. 5: 734-739.
23. Kitamura, T.; Kitamura, Y.; Nakae, J.; Giordano, A.; Cinti, S.; Kkahn, C. R.;
Efstratiadis, A. & Accili, D. (2004) Mosaic analysis of IR function. J. Clin.
Invest. 113: 209-219.
24. Buettner, C.; Patel, R.; Muse, E. D.; Bhanot, S.; Monia, B. P.; McKay, R.;
Obici, S. & Rossetti, L. (2005) Severe impairment in liver insulin signaling
fails to alter hepatic insulin action in conscious mice. J. Clin. Invest. 115:
1306-1313.
25. Duckworth, W. C.; Bennett, R. G. & Hamel, F. G. (1998) Insulin degradation:
Progress and potential. Endocrine Reviews. 19: 608-624.
26. Withers, D. J.; Gutiérrez, J. S.; Towery, H.; Burks, D. J.; Ren, J. M.; Previs,
S.; Zhang, Y.; Bernal, D.; Pons, S.; Shulman, G. I.; Bonner-Weir, S. & White,
M. F. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 391:
900-904.
27. Okada, T.; Liew, C. W.; Hu, J.; Hinault, C.; Michael, M. D.; Krutzfeld, J.; Yin,
C.; Holzember, M.; Stoffel, M. & Kulkarni, R. N. (2007) Insulin receptors
in beta-cells are critical for islet compensatory growth response to insulin
resistance. Proc. Natl. Acad. Sci. USA. 104: 8977-8982.
28. Yakar, S.; Rosen, C. J.; Beamer, W. G.; Ackert-Bicknell, C. L.; Wu, Y.; Liu, J.
L.; Ooi, G. T.; Setser, J.; Frystyk, J.; Boisclair, Y. R. & Leroith, D. (2002)
Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin.
Invest. 110: 771-781.
29. Kulkarni, R. N.; Holzenberger, M.; Shih, D. Q.; Ozcan, U.; Stoffel, M.;
Magnuson, M. A. & Kahn, C. R. (2002) ß-cell-specific deletion of the Igf1
receptor leads to hyperinsulinemia and glucose intolerance but does not alter
ß-cell mass. Nature Genetics 31: 111-115.
30. Schneider, M. R.; Lahm, H.; Wu, M.; Hoeflich, A. & Wolf, E. (2000) Transgenic
mouse models for studying the functions of insulin-like growth factor-binding
proteins. FASEB J. 14: 629-640.
31. Guo, S.; Rena, G.; Cichy, S.; He, X.; Cohen, P. & Unterman, T. (1999)
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by
FKHR and mediates effects of insulin on insulin-like growth factor-binding
protein-1 promoter activity through a conserved insulin response sequence.
J. Biol. Chem. 274: 17184-17192.
32. Gay, E.; Seurin, D.; Babajko, S.; Doublier, S.; Cazillis, M. & Binoux, M. (1997)
Liver-specific expression of human insulin-like growth factor binding protein-
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