Page 118 - 76_01
P. 118
ÓSCAR ESCRIBANO Y COLS. AN. R. ACAD. NAC. FARM.
death in mice homozygous for a null allele of the IR gene. Nat. Genet. 12:
106-109.
6. JoshiI, R. L.; Lamothe, B.; Cordonnier, N.; Mesbah, K.; Monthioux, E.; Jami,
J. & BuchiniI, D. (1996) Targeted disruption of the IR gene in the mouse
results in neonatal lethality. EMBO J. 15: 1542-1547.
7. Okamoto, H.; Nakae, J.; Kitamura, T.; Park, B. C.; Dragatsis, I. & Accili, D.
(2004) Transgenic rescue of IR-deficient mice. J. Clin. Invest. 114: 214-223.
8. Michael, M. D.; Kulkarni, R. N.; Postic, C.; Previs, S. F.; Shulman, G. I.;
Magnuson, M. A. & Kahn, C. R. (2000) Loss of insulin signaling in hepatocytes
leads to severe insulin resistance and progressive hepatic dysfunction. Mol.
Cell. 6: 87-97.
9. Bruning, J. C.; Gautam, D.; Burks, D. J.; Gillete, J.; Schubert, M.; Orban, P.
C.; Klein, R.; Krone, W.; Muller-Wieland, D. & Kahn C. R. (2000) Role of brain
IR in control of body weight and reproduction. Science. 289: 2122-2155.
10. Kulkarni, R. N.; Bruning, J. C.; Winnay, J. N.; Postic, C.; Magnuson, M. A. &
Kahn, C. R. (1999) Tissue-specific knockout of the IR in pancreatic b cells
creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96:
329-339.
11. Bruning, J. C.; Michael, M. D.; Winnay, J. N.; Hayashi, T.; Horsch, D.; Accili,
D.; Goodyear, L. J. & Kahn, C. R. (1998) A muscle-specific IR knockout
exhibits features of the metabolic syndrome of NIDDM without altering
glucose tolerance. Mol. Cell. 2: 559-569.
12. Kühn, R.; Schwenk, F.; Aguet, M. & Rajewsky, K. (1995) Inducible gene
targeting in mice. Science. 269: 1427-1429.
13. Valverde, A. M.; Lorenzo, M.; Pons, S.; White, M. F. & Benito, M. (1998) IRS-
1 and IRS-2 differential signaling in the insulin/IGF-1 pathways in fetal brown
adipocytes. Mol. Endocrinol. 12: 688-697.
14. Guerra, C.; Navarro, P.; Valverde, A. M.; Arribas, M.; Bruning, J.; Kozak, L. P.;
Kahn, C. R. & Benito, M. (2001) Brown adipose tissue-specific IR knockout
shows diabetic phenotype without insulin resistance. J. Clin. Invest. 108: 1205-
1213.
15. Weibel, E. R. (1979) Practical Research Design and Research Design and
Methods for Biological Morphometry. London Academic Press, London.
16. Bonner-Weir, S.; Deery, D.; Leahy, J. L. & Weir, G. C. (1989) Compensatory
growth of pancreatic beta-cells in adult rats after short-term glucose infusion.
Diabetes. 38: 49-53.
17. Guillén, C.; Navarro, P.; Robledo, M.; Valverde, A. M. & Benito, M. (2006)
Differential mitogenic signaling in IR-deficient fetal pancreatic beta-cells.
Endocrinology. 147: 1959-1968.
18. Nevado, C.; Benito, M. & Valverde, A. M. (2008) Role of IR and Balance in IR
Isoforms A and B in Regulation of Apoptosis in Simian Virus 40-immortalized
Neonatal Hepatocytes. Mol. Cell Biol. 19: 1185-1198.
19. Escribano, O.; Arribas, M.; Valverde, A. M. & Benito, M. (2007) IRS-3 mediates
insulin-induced glucose uptake in differentiated IRS-2(–/–) brown adipocytes.
Mol. Cell Endocrinol. 30: 1-9.
42