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CABRERA FIGUEROA, S. & COL. AN. R. ACAD. NAC. FARM.
El número de pacientes cuyas concentraciones plasmáticas de fár-
macos antirretrovirales se han monitorizado es de 381, con un total
de 849 determinaciones. Sólo el 39% de ellas se encontraba dentro de
los márgenes terapéuticos aceptados para estos fármacos. Basándose
en la información farmacocinética, los clínicos han realizado el ajus-
te posológico en 16 pacientes.
La experiencia obtenida desde la implantación del programa de se-
guimiento ha puesto de manifiesto su utilidad para la optimización
de los tratamientos con fármacos antirretrovirales.
Palabras clave: Atención farmacéutica; Monitorización de con-
centraciones plasmáticas; VIH; Ajustes posológicos; Adherencia.
ABSTRACT
Pharmaceutical intervention in the follow-up of antiretroviral
therapy.
The elevated cost of antiretroviral treatment demands close follow-up
to achieve the effectiveness and efficacy of the treatments implemented,
the role of pharmacists in achieving such goals is crucial in the sense that
they are mainly involved in directing antiretroviral treatments aimed at
generating maximum benefit with the available resources. The aim of the
present study was to achieve an appropriate clinical control of HIV+ pa-
tients through the correct use of the antiretroviral drugs prescribed.
The study was carried out for external HIV-patients with antiretro-
viral treatment in a university hospital. One and a half years after im-
plementing a Pharmaceutical Care Program, a total of 853 interviews
were obtained from 386 HIV+ patients (79.6% of the total), achieving
a 9% increase in optimal adherence. In turn, we observed 1060 adver-
se drugs events and 513 drug related problems. In consequence, we
performed 1401 interventions in 365 patients. The degree of patient
acceptance of the program had a mean score of 3.7 (scale 0-4).
The number of patients whose antiretroviral plasma concentra-
tions were monitored was 381, with a total of 849 determinations.
Only 39% of them were within the therapeutic range established for
these drugs. Based on pharmacokinetic information, the clinicians
performed a dosage adjustment in 16 patients.
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