Page 106 - 74_04

W. W. A. SCHAMEL Y COLS. AN. R. ACAD. NAC. FARM

(4) BLUMBERG, R. S.; ALARCON, B.; SANCHO, J.; MCDERMOTT, F. V.; LOPEZ, P.;
BREITMEYER, J. AND TERHORST, C. (1990) Assembly and function of the T
cell antigen receptor. Requirement of either the lysine or arginine residues in
the transmembrane region of the alpha chain. J. Biol. Chem. 265: 14036-
14043.

(5) COSSON, P.; LANKFORD, S. P.; BONIFACINO, J. S. AND KLAUSNER, R. D. (1991)
Membrane protein association by potential intramembrane charge pairs.
Nature. 351: 414-416.

(6) CALL, M. E.; PYRDOL, J.; WIEDMANN, M. AND WUCHERPFENNIG, K. W. (2002)
The organizing principle in the formation of the T cell receptor-CD3 complex.
Cell. 111: 967-979.

(7) PURBHOO, M. A.; IRVINE, D. J.; HUPPA, J. B. AND DAVIS, M. M. (2004) T cell
killing does not require the formation of a stable mature immunological
synapse. Nat. Immunol. 5: 524-530.

(8) IRVINE, D. J.; PURBHOO, M. A.; KROGSGAARD, M. AND DAVIS. M. M. (2002)
Direct observation of ligand recognition by T cells. Nature. 419: 845-849.

(9) DAVIS, M. M.; BONIFACE, J. J.; REICH, Z.; LYONS, D.; HAMPL, J.; ARDEN, B.
AND CHIEN, Y. (1998) Ligand recognition by alpha/beta T cell receptors.
Annu. Rev. Immunol. 16: 523-544.

(10) BONIFACE, J. J.; RABINOWITZ, J. D.; WÜLFING, C.; HAMPL, J.; REICH, Z.;
ALTMAN, J. D.; KANTOR, R. M.; BEESON, C.; MCCONNELL, H. M. AND DAVIS,
M. M. (1998) Initiation of signal transduction through the T cell receptor
requires the peptide multivalent engagement of MHC ligands. Immunity. 9:
459-466.

(11) BACHMANN, M.F.; SPEISER, D. E.; ZAKARIAN, A. AND OHASHI, P. S. (1998)
Inhibition of TCR triggering by a spectrum of altered peptide ligands suggests
the mechanism for TCR antagonism. Eur. J. Immunol. 28: 3110-3119.

(12) COCHRAN, J. R.; CAMERON, T. O. AND STERN, L. J. (2000) The relationship of
MHC-peptide binding and T cell activation probed using chemically defined
MHC class II oligomers. Immunity. 12: 241-250.

(13) PUNT, J. A.; ROBERTS, J. L.; KEARSE, K. P. AND SINGER, A. (1994)
Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3

complex contains one TCRa, one TCRß and two CD3e chains. J. Exp. Med.
180: 587-593.
(14) HOU, X.; DIETRICH, J.; KUHLMANN, J.; WEGENER, A. M. AND GEISLER, C.
(1994) Structure of the T cell receptor in a Ti alpha V beta 2, alpha V beta 8-
positive T cell line. Eur. J. Immunol. 24: 1228-1233.
(15) CALL, M. E.; PYRDOL, J. AND WUCHERPFENNIG, K. W. (2004) Stoichiometry of
the T-cell receptor-CD3 complex and key intermediates assembled in the
endoplasmic reticulum. EMBO J. 16: 2348-2357.
(16) DIETRICH, J.; KASTRUP, J.; LAURITSEN, J. P.; MENNE, C.; VON BULOW, F. AND
GEISLER, C. (1999) TCRzeta is transported to and retained in the Golgi

14