Page 93 - 74_01

VOL. 74 (1), 81-99, 2008 LOS PREMIOS NOBEL 2007 EN FISIOLOGÍA...

BIBLIOGRAFÍA

(1) KOLLER, B. H.; HAGEMANN, L. J.; DOETSCHMAN, T.; HAGAMAN, J. R.; HUANG, S.;
WILLIAMS, P. J.; FIRST, N. L.; MAEDA, N. y SMITHIES, O. (1989): Germ-line trans-
mission of a planned alteration made in a hypoxanthine phosphoribosyl-
transferase gene by homologous recombination in embryonic stem cells. Proc.
Natl. Acad. Sci. U.S.A. 86: 8927-8931.

(2) THOMAS, K. R.; FOLGER K. R.; CAPECCHI, M. R. (1986): High frequency targeting
of genes to specific sites in the mammalian genome. Cell. 44: 419-428.

(3) THOMAS, K. R.; CAPECCHI, M. R. (1986): Introduction of homologous DNA se-
quences into mammalian cells induces mutations in the cognate gene. Natu-
re. 324: 34-38.

(4) THOMAS, K. R.; CAPECCHI, M. R. (1987): Site-directed mutagenesis by gene
targeting in mouse embryo-derived stem cells. Cell. 51: 503-512.

(5) MANSOUR, S. L.; THOMAS, K. R.; CAPECCHI, M. R. (1988): Disruption of the
proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy
for targeting mutations to non-selectable genes. Nature. 336: 348-352.

(6) CAPECCHI, M. R. (1989): The new mouse genetics: altering the genome by gene
targeting. Trends Genet. 5: 70-76.

(7) CAPECCHI, M. R. (1989): Altering the genome by homologous recombination.
Science. 244: 1288-1292.

(8) EVANS, M. J. (1972): The isolation and properties of a clonal tissue culture
strain of pluripotent mouse teratoma cells. J. Embryol. Exp. Morphol. 28:
163-176.

(9) MARTIN, G. R.; EVANS, M. J. (1975): Differentiation of clonal lines of teratocar-
cinoma cells: formation of embryoid bodies in vitro. Proc. Natl. Acad. Sci.
U.S.A. 72: 1441-1445.

(10) PAPAIOANNOU, V. E.; MCBURNEY, M. W.; GARDNER, R. L.; EVANS, M. J. (1975):
Fate of teratocarcinoma cells injected into early mouse embryos. Nature.
258: 70-73.

(11) PAPAIOANNOU, V. E.; GARDNER, R. L.; MCBURNEY, M. W.; BABINET, C.; EVANS, M.
J. (1978): Participation of cultured teratocarcinoma cells in mouse embryo-
genesis. J. Embryol. Exp. Morphol. 44: 93-104.

(12) STEVENS, L. C.; LITTLE, C. C. (1954): Spontaneous Testicular Teratomas in an
Inbred Strain of Mice. Proc. Natl. Acad. Sci. U.S.A. 40: 1080-1087.

(13) STEVENS, L. C. (1960): Embryonic potency of embryoid bodies derived from
a transplantable testicular teratoma of the mouse. Dev. Biol. 2: 285-297.

(14) KLEINSMITH, L. J.; PIERCE, G. B. Jr. (1964): Multipotentiality of single embryo-
nal carcinoma cells. Cancer Res. 24: 1544-1551.

(15) LOVELL-BADGE, R. H.; EVANS, M. J. (1980): Changes in protein synthesis during
differentiation of embryonal carcinoma cells, and a comparison with embryo
cells. J. Embryol. Exp. Morphol. 59: 187-206.

(16) EVANS, M. J.; KAUFMAN, M. H. (1981): Establishment in culture of pluripoten-
tial cells from mouse embryos. Nature. 292: 154-156.

(17) EVANS, M. J. (2001): The cultural mouse. Nat. Med. 7: 1081-1083.

97