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TABLE 2. Characteristics of P2X homomeric purinoceptors(cont.) VOL. 73 (4), 1127-1157, 2007

Receptor Agonists Antagonists Desensi- Major
tization distribution

P2X5 ATP=2MeSATP=Ap4A> PPADS>TNP-ATP> Slow Trigeminus ganglia, spi-
a, ß-meATP>BzATP Suramin>RB 2 (µM) nal cord, proliferati-
ADP inactive ve skin cells, thymus,
bladder

P2X6 2MeSATP=ATP= TNP-ATP>PPADS Slow Brain, spinal cord,
a,ß-meATP>Ap5A Suramin insensitive sympathetic ganglia
>ADP
PHYSIOLOGICAL ROLE OF EXTRACELLULAR...
P2X7 BzATP>2MeSATP A-74003=A-438079 Fast Retinal ganglia, immune
(rat, human) cells, brain, spinal cord,
>>ATP BBG (nM) (rat) skin, pancreas.
PPADS=TNP-ATP (nM)
a,ß-meATP and ADP KN-62 (nM)
inactive (human, mouse)
Suramin (mM)
(rat, human)

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