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1134 TABLE 1. Characteristics of P2Y purinoceptors (cont.) M.ª TERESA MIRAS-PORTUGAL Y COLS.

Receptor Agonist Antagonist Signal Major distribution
transduction
mechanisms

P2Y12 2MeSADP=2MeSATP AR-C69931,AR-C66096, Gi Human platelets, brain
>>ADP>>ATP Clopidogrel, AC Inhibition
UTP, UDP inactives Tioclopidine,
RB 2, Suramin,
2MeSAMP,
CT50547, AZD6140,
INS49266, PSB0413,
PPADS inactive,
BzATP (rat)

P2Y13 2MeSADP=2MeSATP>ADP AR-C69931 Gq/G11/Gi Spleen, brain, glial cells,
>>ATP >PPADS>Suramin PLCß/IP3/Ca2+ spinal cord, linfatic ganglia
2MeSAMP AC Inhibition endothelial cells ANAL. REAL ACAD. NAC. FARM.
UTP, UDP inactives MRS2211

P2Y14 UDP-glucose>UDP- ¿? Gq/G11/Gi Placenta, stomach, gut,
galactose>UDP-Glucuronic brain, spleen, heart, lung
>UDP-N-acetilglucosamine
ATP, ADP, UTP, UDP
inactives