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M.ª TERESA MIRAS-PORTUGAL Y COLS. ANAL. REAL ACAD. NAC. FARM.

P2X receptors from the presynaptic area are able to induce
calcium dependent exocytotic release upon stimulation. The
nucleotide effect is dose dependent and the induced release of
classical neurotransmitters such as: acetylcholine, glutamate, GABA

FIGURE 3. Experimental based distribution of P2X receptors in CNS. P2X
receptors exhibit a specific distribution along the axodendritic fibres (A). P2X1
(red) and P2X4 (green) are preferently located at the dendrites and somas. P2X3
(yellow) and P2X7 (pink) are mainly at the axons. P2X2 subunit expression (blue)
is restricted to the somas. The activation of the different P2X receptors produces
an increase in intracellular calcium levels and activates different signalling mecha-

nisms.

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