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M.ยช TERESA MIRAS-PORTUGAL Y COLS. ANAL. REAL ACAD. NAC. FARM.
subunit is expressed, it is probably that the majority of P2X receptors
are heteromeric in nature (18). Unlike P2Y, these P2X receptors only
recognize adenine nucleotides, in concentrations able to be reached
in physiological conditions.
FIGURE 1. Signal transduction mechanisms of P2Y receptors. In general, P2Y
receptors are coupled, through G protein, to PLC, and induce intracellular calcium
mobilization, and finally, PKC activation. In addition, P2Y activation can induce
other signalling mechanisms such as PLD, PLA2, MAPK and NOS activation.
Moreover, P2Y receptors can be coupled to AC through Gi proteins
and to potassium and calcium channels.
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