Page 317 - 73_04
P. 317
An. R. Acad. Nac. Farm., 2007, 73 (4): 1127-1157
Revisión
Physiological role of extracellular nucleotides at
the central nervous system: signalling through
P2X and P2Y receptors
Recibido el 18 de octubre de 2007
MARÍA TERESA MIRAS-PORTUGAL*, PATRICIA MARÍN-
GARCÍA, LUZ MARÍA G. CARRASQUERO, ESMERILDA
G. DELICADO, MIGUEL DÍAZ-HERNÁNDEZ, JUAN IGNACIO
DÍAZ-HERNÁNDEZ, MARÍA DIEZ-ZAERA, M.ª DOLORES FIDEU,
M.ª ROSA GÓMEZ-VILLAFUERTES, JAVIER GUALIX, DAVID
LEÓN, MÍRIAM LEÓN-OTEGUI, FELIPE ORTEGA, RAQUEL
PÉREZ-SEN, ELVIRA SALAS, JESÚS SÁNCHEZ-NOGUEIRO
Departamento de Bioquímica y Biología Molecular IV, Facultad de
Veterinaria. Universidad Complutense de Madrid
ABSTRACT
In the last few years nucleotide receptors, the ionotropic P2X1-7 subunits and
the metabotropic P2Y1, 2, 4, 6, 11, 12, 13, 14, have acquired an excepcional importance due
to their strategic location in organs and tissues, their great variety along with the
complexity of the associated signalling pathways and the first evidence of the
serious alterations entailed in their dysfunctions. Our group has been pioneer in
the characterization of these receptors in the nervous system, where we defined
their location and functionality. The abundant presence, at a presynaptic level, of
P2X3 and P2X7 should be emphasized, where by means of calcium intake they
induce neurotransmitter exocytosis, such as glutamate, GABA, catecholamines and
acetylcholine among others, as described in previous works by our group. In addi-
* Presidenta de la Real Academia Nacional de Farmacia.
Dpto. de Bioquímica y Biología Molecular IV. Facultad de Veterinaria.
Universidad Complutense de Madrid.
Av. Puerta de Hierro, s/n. 28040. Madrid.
Tf.: 91 394 38 94
Fax: 91 394 39 09
e-mail: mtmiras@vet.ucm.es
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