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P. 139
VOL. 69 (1), MICROCÁPSULAS ORALES DE LIBERACIÓN CONTROLADA DE NAPROXENO
Figure 4. Release profiles of E (RL PO), F (RL PO/Cutina HR), G (RL
PO/Cutina KD 16) and D (RL PO/Cutina MD) formulations.
100 E
F
80 G
H
60
40
20
0
0 2 4 6 8 10 12
Time (h)
The results obtained in the release studies are shown in Table 4. It
is possible to observe that the release kinetics from the microcapsules
containing naproxen followed the Higuchi equation up to 79.9% of the
cumulative drug release.
As expected, a higher release rate was obtained when the Eudragit
RS PM content decreased or when Eudragit RL PO increased. When 0%,
25%, 50%, 75% and 100% of Eudragit RS PM was incorporated into the
formulations, the amount of released naproxen decreased to 79.9%,
66.3%, 42.2%, 19.9% and 16.5% after 12 h, respectively.
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