Page 59 - 66_04

VOL. 66, (4) 2000 UN SIGLO DE GENÉTICA

(15) 12 GORDON,J.W.; SCANGOS,G.A.; PLOTKIN,D.J.; BARBOSA,J.A.;
RUDDLE, F.H. 1980. Genetic transformation of mouse embryos by
microinjection of purified DNA. Proc.Nat.Acad.Sci., 77:7380-7384.

(16) 13 GORDON,J.W.; RUDDLE,F.H. 1981. Integration and stable germ line
transmissions of genes injected into mouse pronuclei. Science, 214:1244-
1246.

(17) 14 PALMITER,R.D.; BRINSTER,R.L.; HAMMER,R.E.; TRUM-
BAUER,M.E.; ROSENFELD,M.G.; BIRNBERG,N.C.; EVANS,R.M.
(1982) Dramatic growth of mice that develop from eggs microinjected with
metallothionein-growth hormone fusion genes. Nature, 300:611-615.

(18) PALMITER,R.D.; NORSTEDT,G.; GELINAS,R.E.; HAMMER,R.E.;
BRINSTER,R.L. (1983) Metallothionein-human GH fusion genes stimu-
late growth of mice. Science, 222:809-814.

(19) 15 HAMMER, R.E.; POURSEL, V.G.; REXROAD, C.E.(Jr); WALL, R.J.;
BOLT, D.J.; EBERT, K.M.; PALMITER, R.D.; BRINSTER, R.L. 1985.
Production of transgenic rabbits, sheep and piggs by microinjection. Na-
ture, 315:680-683

(20) 16 Para revisiónes ver CHEN,T.T.; POWERS,D.A. (1990) Transgenic fish.
Trends in Biotechnology, 8:209-215.

(21) BIALY,H. (1991) Transgenic pharming comes of age. Bio/technology,
9:786-787.

(22) SANG,H. (1994) Transgenic chickens: methods and potential applications.
Trends in Biotechnology, 12:415-420.

(23) VELANDER,W.H.; LUBON,H.; DROHAN,W.N. (1997). Transgenic live-
stock as drug factories. Scient. Amer., 276(1):54-58.

(24) 17 McCREATH,K.J.; HOWCROFT,J.; CAMPBELL,K.H.S.; COL-
MAN,A.; SCHNIEKE,A.E.; KIND,A.J. 2000. Production of gene-targeted
sheep by nuclear transfer from cultured somatic cells. Nature, 405:1066-
1069

(25) 18 CLARK,A.J.; BESSOS,H.; BISHOP,J.O.; BROWN,P.; HARRIS,S.;
LATHER,R.; McCLENAGHAN,M.; PROWSE,C.; SIMONSJ.P.;
WHITELAW,C.B.A.; WILMUT,I. 1989. Expression of human antihemo-
philic factor IX in the milk of transgenic sheep. Biotechnology, 7:487-492.

(26) EBERT,K.M.; SELGRATH,J.P.; di TULLIO,P.; DENMAN,J.;
SMITH,T.E.; MEMON,M.A.; SCHINDLER,J.; MONASTERSKY,G.M.;
VITALE,J.A.; GORDON,K. 1991. Transgenic production of a variant of
human tissue-type plasminogen activator in goat milk: generation of trans-
genic goats and analysis of expression. Biotechnology, 9:835-838.

57