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Multifactorial role of flavonoids in prevention and treatment of various cancers
hesperitin, luteolin, proanthocyanidins. Flavonoids exhibit
anti-oxidant, anti-inflammatory, anti-tumor, anti-
angiogenesis activity. Flavonoids modulate the biological
events in cancer progression by effecting different
signaling cascades. They have been shown to inhibit
several key transcriptional factors and are capable of
inducing apoptosis and cell death. Quercitin, a well-
studied flavonoid induced G2/M phase cell cycle halt and
mitochondrial programed cell death through a P-53
dependent mechanism in HeLa cells (human cervical
cancer cells) (43).
Further studies and biochemical tests should be carried
out to validate the relationship between the structure and
function of specific flavonoids. This validation is
important if flavonoids are to be used commercially for the
treatment of cancer. Moreover, the lack of epidemiological
studies that focus on the intake of pure doses of
flavonoids, is also a major area that lacks data.
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