Page 49 - 82_02
P. 49

A historical overview of protein kinase PKR…                 175. Lu B, Nakamura T, Inouye K, et al. Novel role of
                                                                  PKR in inflammasome activation and HMGB1
163. Chang RC, Suen KC, Ma CH, Elyaman W, Ng HK,                  release. Nature 2012; 488, 670–674.
     Hugon J. Involvement of double-stranded
     RNAdependent protein kinase and phosphorylation of
     eukaryotic initiation factor-2alpha in neuronal
     degeneration. J. Neurochem. 2002; 83, 1215–1225.

164. Onuki R, Bando Y, Suyama E, et al. An RNA-
     dependent protein kinase is involved in tunicamycin-
     induced apoptosis and Alzheimer’s disease. EMBO
     J.2004; 23, 959–968.

165. Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby
     LM, Bredesen DE. Double-stranded RNAdependent
     protein kinase, PKR, binds preferentially to
     Huntington’s disease (HD) transcripts and is activated
     in HD tissue. Hum. Mol. Genet. 2001; 10, 1531–1538.

166. Bando Y, Onuki R, Katayama T, et al. Double-strand
     RNA dependent protein kinase (PKR) is involved in
     the extrastriatal degeneration in Parkinson’s disease
     and Huntington’s disease. Neurochem. Int. 2005; 46,
     11–18.

167. Mouton-Liger F, Paquet C, Dumurgier J, et al.
     Oxidative stress increases BACE1 protein levels
     through activation of the PKR-eIF2alpha pathway.
     Biochim. Biophys. Acta 2012; 1822, 885–896.

168. Bose A, Mouton-Liger F, Paquet C, et al. Modulation
     of tau phosphorylation by the kinase PKR:
     implications in Alzheimer’s disease. Brain Pathol.
     2011;21, 189–200.

169. Paquet C, Dumurgier J, Hugon J. Pro-Apoptotic
     Kinase Levels in Cerebrospinal Fluid as Potential
     Future Biomarkers in Alzheimer's Disease. Front
     Neurol. 2015;6:168.

170. Zhu PJ, Huang W, Kalikulov D, et al. Suppression of
     PKR promotes network excitability and enhanced
     cognition by interferon-gamma-mediated
     disinhibition. Cell 2011; 147, 1384–1396.

171. Couturier J, Paccalin M, Morel M, et al. Prevention
     of the beta-amyloid peptide-induced inflammatory
     process by inhibition of double-stranded RNA-
     dependent protein kinase in primary murine mixed co-
     cultures. J. Neuroinflammation 2011; 8, 72.

172. Couturier J, Morel M, Pontcharraud R, et al.
     Interaction of double-stranded RNA-dependent
     protein kinase (PKR) with the death receptor signaling
     pathway in amyloid beta (Abeta)- treated cells and in
     APPSLPS1 knock-in mice. J. Biol. Chem. 2010; 285,
     1272–1282.

173. Cabanski M, Steinmüller M, Marsh LM, Surdziel
     E, Seeger W, Lohmeyer J. PKR regulates
     TLR2/TLR4-dependent signaling in murine alveolar
     macrophages. Am J Respir Cell Mol Biol. 2008;
     38(1):26-31.

174. Carvalho-Filho MA, Carvalho BM, Oliveira AG, et
     al. Double-stranded RNA-activated protein kinase is a
     key modulator of insulin sensitivity in physiological
     conditions and in obesity in mice. Endocrinology
     2012; 153, 5261–5274.

@Real Academia Nacional de Farmacia. Spain                   167
   44   45   46   47   48   49   50   51   52   53   54