Page 44 - 82_02

32. Dey M, Cao C, Dar AC, et al. Mechanistic link
between PKR dimerization, autophosphorylation, and
eIF2alpha substrate recognition. Cell 2005; 122, 901–
913
33. Wu S, Kumar KU, Kaufman RJ. Identification and
requirement of three ribosome binding domains in
dsRNA-dependent protein kinase (PKR),
Biochemistry 1998; 37 (39) 13816-13826.
34. Zhou HR, He K, Landgraf J, Pan X, Pestka JJ. Direct
activation of ribosome-associated double-stranded
RNA-dependent protein kinase (PKR) by
deoxynivalenol, anisomycin and ricin: a new model
for ribotoxic stress response induction. Toxins
(Basel). 2014; 6(12):3406-25.
35. Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel
proteins: evolutionarily conserved mediators of
immune responses. Annu. Rev. Immunol. 1998;
16:225–260.
36. Ghosh S, Karin M. Missing pieces in the NF-kappaB
puzzle. Cell 2002;109 S81-S96
37. Hinz M, Scheidereit C. The I?B kinase complex
in NF-?B regulation and beyond. EMBO Rep. 2014;
15(1):46-61.
38. Visvanathan KV, and Goodbourn S. Double-stranded
RNA activates binding of NF-kappa B to an inducible
element in the human betainterferon promoter. EMBO
J. 1989; 8:1129–1138.
39. Maran AR, Maitra K, Kumar A, et al. Blockage of
NF-kappa B signaling by selective ablation of an
mRNA target by 2-5A antisense chimeras. Science
1994; 265:789–792.
40. Yang, YL, Reis LF, Pavlovic J, et al. Deficient
signaling in mice devoid of double-stranded RNA-
dependent protein kinase. EMBO J. 1995; 14: 6095–
6106.
41. Gil J, Alcami J, Esteban M. Induction of apoptosis by
doublestranded-RNA-dependent protein kinase (PKR)
involves the alpha subunit of eukaryotic translation
initiation factor 2 and NF-kB. Mol. Cell. Biol. 1999;
19:4653–4663.
42. Gil J, Alcami J, Esteban M. Activation of NF-kappa B
by the dsRNA-dependent protein kinase, PKR,
involves the I kappa B kinase complex. Oncogene
2000; 19:1369–1378.1999.
43. Kumar A, Haque J, Lacoste J, Hiscott J, Williams BR.
Double-stranded RNA-dependent protein kinase
activates transcription factor NF-kappa B by
phosphorylating I kappa B. Proc. Natl. Acad. Sci.
USA 1994; 91:6288–6292.
44. Kumar A, Yang YL, Flati V, et al. Deficient cytokine
signalling in mouse embryo fibroblasts with a targeted
deletion in the PKR gene: role of IRF-1 and NF-
kappaB. EMBO J. 1997 ; 16:406–416.
45. Yamaoka SG, Courtois C, Bessia ST, et al.
Complementation cloning of NEMO, a component of
the IkappaB kinase complex essential for NF-kappaB
activation. Cell 1998 ; 93:1231–1240.
162
María Ángel García Chaves
46. Gil J, Rullas J, Garcia MA, Alcami J, Esteban M. The
catalytic activity of dsRNA-dependent protein kinase,
PKR, is required for NF-kappaB activation. Oncogene
2001; 20:385–394.
47. Chu WM, Ostertag D, Li ZW, et al. JNK2 and
IKKbeta are required for activating the innate
response to viral infection. Immunity 1999; 11:721–
731.
48. Bonnet MC, Daurat C, Ottone C, Meurs EF. The N-
terminus of PKR is responsible for the activation of
the NF-kappaB signaling pathway by interacting with
the IKK complex. Cell Signal. 2006;18(11):1865-75.
49. Dabo S, Meurs EF. dsRNA-Dependent Protein Kinase
PKR and its Role in Stress, Signaling and HCV
Infection. Viruses 2012,;4, 2598-2635.
50. Chung JY, Park YZ, Ye H, Wu H. All TRAFs are not
created equal: common and distinct molecular
mechanisms of TRAF-mediated signal transduction. J.
Cell Sci. 2002; 115:679–688.
51. Gil J, Garcia MA, P. Gomez-Puertas P, et al. TRAF
family proteins link PKR with NF-kB activation. Mol.
Cell. Biol. 2004; 24:4502–4512.
52. Oganesyan G, Saha SK, Guo B, et al. Critical role of
TRAF3 in the Toll-like receptor-dependent and -
independent antiviral response. Nature 2006;
439:208– 211.
53. Ogolla PS, Portillo JA, White CL. The protein kinase
double-stranded RNA-dependent (PKR) enhances
protection against disease cause by a non-viral
pathogen. PLoS Pathog. 2013;9(8):e1003557.
54. Munir M, Berg M. The multiple faces of
proteinkinase R in antiviral defense. Virulence 2013;
4:1, 85–89.
55. Schulz O, Pichlmair A, Rehwinkel J. Protein kinase R
contributes to immunity against specific viruses by
regulating interferon mRNA integrity. Cell Host
Microbe 2010; 7:354-61.
56. Yoo JS, Takahasi K, Ng CS, et al. DHX36
enhances RIG-I signaling by facilitating PKR-
mediated antiviral stress granule formation. PLoS
Pathog. 2014;10(3):e1004012.
57. Onomoto K, Jogi M, Yoo JS, et al. Critical role of an
antiviral stress granule containing RIG-I and PKR in
viral detection and innate immunity. PLoS One.
2012;7(8):e43031.
58. Ramana CV, Grammatikakis N, Chernov M, et al.
Regulation of c-myc expression by IFN-gamma
through Stat1-dependent and -independent pathways,
EMBO J. 2000; 19 (2) 263-272.
59. Lee JH, Park EJ, Kim OS, et al. Doublestranded
RNA-activated protein kinase is required for the LPS-
induced activation of STAT1 inflammatory signaling
in rat brain glial cells, Glia 2005; 50 (1) 66-79.
60. Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S,
Williams BR. Protein kinase PKR is required for
platelet-derived growth factor signalling of c-fos gene
@Real Academia Nacional de Farmacia. Spain