Page 43 - 82_02
P. 43
A historical overview of protein kinase PKR… 19. Donnelly N, Gorman AM, Gupta S, Samali A. The
eIF2alpha kinases: their structures and functions. Cell.
6. Metz DH, Esteban M. Interferon inhibits viral protein Mol. Life Sci 2013; 70, 3493–3511.
synthesis in L cells infected with vaccinia virus.
Nature 1962;238(5364):385-8 20. Patel S, Blose JM, Sokoloski JE, et al. Specificity of
the double-stranded RNAbinding domain from the
7. Friedman RM, Metz DH, Esteban M, et al. RNA-activated protein kinase PKR for double-
Mechanism of interferon action: inhibition of viral stranded RNA: insights from thermodynamics and
messenger ribonucleic acid translation in L-cell small-angle X-ray scattering. Biochemistry 2012; 51,
extracts. J Virol 1972;10(6):1184-98. 9312–9322
8. Kerr IM, Brown RE, Ball LA, et al. Increased 21. Morel M, Couturier J, Lafay-Chebassier C, Paccalin
sensitivity of cell-free protein synthesis to double- M, Page G. PKR, the double stranded RNA-dependent
stranded RNA after interferon treatment. Nature 1974; protein kinase as a critical target in Alzheimer’s
250:57-59. disease. J Cell Mol Med 2009;13:1476-88.
9. Roberts WK, Hovanessian A, Brown RE, Clemens 22. Garcia MA, Carrasco E, Aguilera M, et al. The
MJ, Kerr IM. Interferon-mediated protein kinase and chemotherapeutic drug 5-fluorouracil promotes PKR-
low-molecular-weight inhibitor of protein synthesis. mediated apoptosis in a p53-independent manner in
Nature 1976;264:477-480. colon and breast cancer cells. PLoS ONE 2011; 6,
e23887.
10. Farrell PJ, Balkow K, Hunt T, Jackson RJ, Trachsel
H. Phosphorylation of initiation factor elF-2 and the 23. Marques JT, White CL, Peters GA, Williams BR, Sen
control of reticulocyte protein synthesis. Cell 1977;11 GC. The role of PACT in mediating gene induction,
(1):187-200. PKR activation, and apoptosis in response to diverse
stimuli. J. Interferon Cytokine Res. 2008; 28, 469–
11. Krust B, Galabru J, Hovanessian AG. Further 476.
characterisation of the protein kinase activity mediated
by interferon in mouse and human cells. J Biol Chem 24. Singh M, Patel RC. Increased interaction between
1984;259(13):8494-8. PACT molecules in response to stress signals is
required for PKR activation. J. Cell. Biochem. 2012;
12. Laurent AG, Krust B, Galabru J, Svab J, Hovanessian 113, 2754–2764.
AG. Monoclonal antibodies to an interferon-induced
Mr 68,000 protein and their use for the detection of 25. Jiang Z, Zamanian-Daryoush M, Nie H, et al. Poly(I-
double-strandedRNA-dependent protein kinase in C)-induced Toll-like receptor 3 (TLR3)-mediated
human cells. Proc Natl Acad Sci USA 1985;82(13): activation of NFkappa B and MAP kinase is through
4341-5. an interleukin-1 receptorassociated kinase (IRAK)-
independent pathway employing the signalling
13. Meurs E, Chong K, Galabru J, et al. Molecular components TLR3-TRAF6-TAK1-TAB2-PKR. J.
cloning and characterization of the human double- Biol. Chem. 2003; 278 (19) 16713-16719.
stranded RNA-activated protein kinase induced by
interferon, Cell 1990; 62 (2) 379-390. 26. Williams BR. Signal integration via PKR, Sci. STKE
2001; 89-RE2.
14. Galabru J, Katze MG, Robert N, Hovanessian AG.
The binding of double-stranded RNA and adenovirus 27. Clemens MJ. PKR- a protein kinase regulated by
VAI RNA to the interferon-induced protein kinase, double-stranded RNA, Int J. Biochem Cell Biol. 1997;
Eur. J. Biochem. 1989; 178 (3) 581-589. 29 (7) 945-949.
15. Hovanessian AG, Galabru J, Riviere Y, Montagnier L. 28. Nanduri S, Carpick B, Yang Y, Williams BR, Qin J.
Efficiency of poly(A).poly(U) as an adjuvant. 1H, 13C, 15N resonance assignment of the 20 kDa
Immunol. Today 1988; 9 (6) 161-162. double stranded RNA binding domain of PKR, J.
Biomol. 1998; NMR 12 (2) 349-351.
16. Clemens MJ, Hershey JW, Hovanessian AC, et al.
PKR: proposed nomenclature for the RNA-dependent 29. Dey M, Cao C, Dar AC, et al. Mechanistic link
protein kinase induced by interferon, J. Interferon between PKR dimerization, autophosphorylation, and
Res.1993; 13 (3) 241. eIF2alpha substrate recognition, Cell 2005;122 (6)
901-913.
17. Kuhen KL, Shen X, Carlisle ER, Richardson AL,
Weier HU, Tanaka H, Samuel CE. Structural 30. Zhang F, Romano PR, Nagamura-Inoue T, et al.
organization of the human gene (PKR) encoding an Binding of double-stranded RNA to protein kinase
interferon-inducible RNA-dependent protein kinase PKR is required for dimerization and promotes critical
(PKR) and differences from its mouse homolog. autophosphorylation events in the activation loop, J.
Genomics 1996; 36:197–201. Biol. Chem. 2001; 276 (27) 24946-24958.
18. Kuhen KL and Samuel CE. Isolation of the interferon- 31. Su Q, Wang S, Baltzis D, Qu LK, Wong AH,
inducible RNA-dependent protein kinase Pkr Koromilas AE. Tyrosine phosphorylation acts as a
promoter and identification of a novel DNA element molecular switch to full-scale activation of the
within the 5'-flanking region of human and mouse Pkr eIF2alpha RNA-dependent protein kinase, Proc. Natl.
genes. Virology 1997; 6;227(1):119-30. Acad. Sci. U.S.A. 2006; 103 (1) 63-68.
@Real Academia Nacional de Farmacia. Spain 161