Page 131 - 82_02
P. 131
The new levels of redox regulation of S-adenosylmethionine synthesis
with intersubunit active sites. Biochem J 2002; 361: hypermethioninemia is associated with a mutation in
307-15.
the human methionine adenosyltransferase 1A gene.
59. Gonzalez B, Pajares MA, Hermoso JA, et al. The Am J Human Genet 1997; 60: 540-6.
crystal structure of tetrameric methionine
adenosyltransferase from rat liver reveals the 73. Chamberlin ME, Ubagai T, Mudd SH, et al.
methionine-binding site. J Mol Biol 2000; 300: 363-
75. Methionine adenosyltransferase I/III deficiency: novel
60. Gonzalez B, Pajares MA, Hermoso JA, Guillerm D, mutations and clinical variations. Am J Human Genet
Guillerm G, Sanz-Aparicio J. Crystal structures of
methionine adenosyltransferase complexed with 2000; 66:347-55.
substrates and products reveal the methionine-ATP
recognition and give insights into the catalytic 74. Hazelwood S, Bernardini I, Shotelersuk V, et al.
mechanism. J Mol Biol 2003; 331: 407-16. Normal brain myelination in a patient homozygous for
61. Deigner HP, Mato JM, Pajares MA. Study of the rat a mutation that encodes a severely truncated
liver S-adenosylmethionine synthetase active site with
8-azido ATP. Biochem J 1995; 308: 565-71. methionine adenosyltransferase I/III. Am J Human
62. Sanchez-Perez GF, Gasset M, Calvete JJ, Pajares MA. Genet 1998; 75: 395-400.
Role of an intrasubunit disulfide in the association
state of the cytosolic homo-oligomer methionine 75. Gasso M, Rubio M, Varela G, et al. Effects of S-
adenosyltransferase. J Biol Chem 2003; 278: 7285-93. adenosylmethionine on lipid peroxidation and liver
63. Pajares MA, Corrales FJ, Ochoa P, Mato JM. The role fibrogenesis in carbon tetrachloride-induced cirrhosis.
of cysteine-150 in the structure and activity of rat liver
S-adenosyl-L-methionine synthetase. Biochem J 1991; J Hepatol 1996; 25: 200-5.
274: 225-9.
76. Corrales F, Gimenez A, Alvarez L, et al. S-
64. Mingorance J, Alvarez L, Sanchez-Gongora E, Mato adenosylmethionine treatment prevents carbon
JM, Pajares MA. Site-directed mutagenesis of rat liver
S-adenosylmethionine synthetase. Identification of a tetrachloride-induced S-adenosylmethionine
cysteine residue critical for the oligomeric state.
Biochem J 1996; 315: 761-6. synthetase inactivation and attenuates liver injury.
65. Avila MA, Corrales FJ, Ruiz F, et al. Specific Hepatology 1992; 16: 1022-7.
interaction of methionine adenosyltransferase with
free radicals. BioFactors 1998; 8: 27-32. 77. Shafqat N, Muniz JR, Pilka ES, et al. Insight into S-
adenosylmethionine biosynthesis from the crystal
66. Martinez-Chantar ML, Pajares MA. Assignment of a structures of the human methionine
single disulfide bridge in rat liver methionine
adenosyltransferase. Eur J Biochem 2000; 267: 132-7. adenosyltransferase catalytic and regulatory subunits.
67. Iloro I, Chehin R, Goni FM, Pajares MA, Arrondo JL. Biochem J 2013; 452: 27-36.
Methionine adenosyltransferase alpha-helix structure
unfolds at lower temperatures than beta-sheet: a 2D- 78. Murray B, Antonyuk SV, Marina A, et al. Structure
IR study. Biophys J 2004; 86: 3951-8. and function study of the complex that synthesizes S-
68. Houry WA, Frishman D, Eckerskorn C, Lottspeich F, adenosylmethionine. IUCrJ 2014; 1: 240-9.
Hartl FU. Identification of in vivo substrates of the
chaperonin GroEL. Nature 1999; 402:147-54. 79. Avila MA, Berasain C, Torres L, et al. Reduced
69. Pajares MA, PĂ©rez C. The relationship between human mRNA abundance of the main enzymes involved in
MAT1A mutations and disease: a folding and methionine metabolism in human liver cirrhosis and
association problem? In: Walters EC, ed. Protein hepatocellular carcinoma. J Hepatol 2000; 33: 907-14.
Folding. New York: Nova Science Publishers 2011;
pp. 261-87. 80. Huang ZZ, Mato JM, Kanel G, Lu SC. Differential
70. Mudd SH. Hypermethioninemias of genetic and non- effect of thioacetamide on hepatic methionine
genetic origin: A review. Am J Med Genet C Semin adenosyltransferase expression in the rat. Hepatology
Med Genet 2011; 157C: 3-32. 1999; 29: 1471-8.
71. Chien YH, Abdenur JE, Baronio F, et al. Mudd's 81. Lu SC, Alvarez L, Huang ZZ, et al. Methionine
disease (MAT I/III deficiency): a survey of data for
MAT1A homozygotes and compound heterozygotes. adenosyltransferase 1A knockout mice are
Orphanet J Rare Dis 2015; 10: 99. predisposed to liver injury and exhibit increased
expression of genes involved in proliferation. Proc
72. Chamberlin ME, Ubagai T, Mudd SH, Levy HL, Chou
JY. Dominant inheritance of isolated Natl Acad Sci USA 2001; 98: 5560-5.
82. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG,
Leonard JV, Chou JY. Demyelination of the brain is
associated with methionine adenosyltransferase I/III
deficiency. J Clin Invest 1996; 98: 1021-7.
83. Reytor E, Perez-Miguelsanz J, Alvarez L, Perez-Sala
D, Pajares MA. Conformational signals in the C-
terminal domain of methionine adenosyltransferase
I/III determine its nucleocytoplasmic distribution.
FASEB J 2009; 23: 3347-60.
84. Robbins J, Dilworth SM, Laskey RA, Dingwall C.
Two interdependent basic domains in nucleoplasmin
nuclear targeting sequence: identification of a class of
bipartite nuclear targeting sequence. Cell 1991; 64:
615-23.
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