Page 132 - 82_02

85. Sessler RJ, Noy N. A ligand-activated nuclear María Ángeles Pajares
localization signal in cellular retinoic acid binding @Real Academia Nacional de Farmacia. Spain
protein-II. Mol Cell 2005; 18: 343-53.

86. Turpin P, Ossareh-Nazari B, Dargemont C. Nuclear
transport and transcriptional regulation. FEBS Lett
1999; 452: 82-6.

87. Katoh Y, Ikura T, Hoshikawa Y, et al. Methionine
Adenosyltransferase II Serves as a Transcriptional
Corepressor of Maf Oncoprotein. Mol Cell 2011; 41:
554-66.

88. Gibson BA, Kraus WL. Small molecules, big effects: a
role for chromatin-localized metabolite biosynthesis in
gene regulation. Mol Cell 2011; 41: 497-9.

89. Cabrero C, Duce AM, Ortiz P, Alemany S, Mato JM.
Specific loss of the high-molecular-weight form of S-
adenosyl-L-methionine synthetase in human liver
cirrhosis. Hepatology 1988; 8: 1530-4.

90. Stramentinoli G, Gualano M, Ideo G. Protective role of
S-adenosyl-L-methionine on liver injury induced by
D-galactosamine in rats. Biochem Pharmacol 1978;
27: 1431-3.

91. Friedel HA, Goa KL, Benfield P. S-adenosyl-L-
methionine. A review of its pharmacological
properties and therapeutic potential in liver
dysfunction and affective disorders in relation to its
physiological role in cell metabolism. Drugs 1989; 38:
389-416.

92. Schnackenberg LK, Chen M, Sun J, et al. Evaluations
of the trans-sulfuration pathway in multiple liver
toxicity studies. Toxicol Appl Pharmacol 2009; 235:
25-32.

93. Delgado M, Garrido F, Perez-Miguelsanz J, et al.
Acute liver injury induces nucleocytoplasmic
redistribution of hepatic methionine metabolism
enzymes. Antioxid Redox Signal 2014; 20: 2541-54.

94. Baillie TA, Rettie AE. Role of biotransformation in
drug-induced toxicity: influence of intra- and inter-
species differences in drug metabolism. Drug Metab
Pharmacokinet 2011; 26: 15-29.

95. Shiraki N, Shiraki Y, Tsuyama T, et al. Methionine
metabolism regulates maintenance and differentiation
of human pluripotent stem cells. Cell Metab 2014; 19:
780-94.

96. Gil B, Casado M, Pajares MA, et al. Differential
expression pattern of S-adenosylmethionine
synthetase isoenzymes during rat liver development.
Hepatology 1996; 24: 876-81.

97. Pajares MA, Alvarez L, Perez-Sala D. How are
mammalian methionine adenosyltransferases
regulated in the liver? A focus on redox stress. FEBS
Lett 2013; 587: 1711-6.

98. Pajares MA, Corrales F, Duran C, Mato JM, Alvarez
L. How is rat liver S-adenosylmethionine synthetase
regulated? FEBS Lett 1992; 309: 1-4.

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