Page 129 - 82_02
P. 129
The new levels of redox regulation of S-adenosylmethionine synthesis
adenosinetriphosphate. J Biol Chem 1953; 204: 403- and Alzheimer's disease. J Alzheimers Dis 2009; 16:
467-70.
16.
18. Popp J, Lewczuk P, Linnebank M, et al. Homocysteine
3. Fontecave M, Atta M, Mulliez E. S- Metabolism and Cerebrospinal Fluid Markers for
adenosylmethionine: nothing goes to waste. Trends Alzheimer's Disease. J Alzheimers Dis 2009; 18: 819-
28.
Biochem Sci 2004; 29: 243-9.
19. Refsum H, Helland S, Ueland PM. Fasting plasma
4. Pajares MA, Markham GD. Methionine homocysteine as a sensitive parameter of antifolate
effect: a study of psoriasis patients receiving low-dose
adenosyltransferase (s-adenosylmethionine methotrexate treatment. Clin Pharmacol Ther 1989;
46: 510-20.
synthetase). Adv Enzymol Relat Areas Mol Biol
20. Delgado M, Perez-Miguelsanz J, Garrido F, et al. Early
2011; 78: 449-521. effects of copper accumulation on methionine
metabolism. Cell Mol Life Sci 2008; 65: 2080-90.
5. Markham GD, Pajares MA. Structure-function
relationships in methionine adenosyltransferases. Cell 21. Medici V, Shibata NM, Kharbanda KK, et al. Maternal
Mol Life Sci 2009; 66: 636-48. choline modifies fetal liver copper, gene expression,
DNA methylation, and neonatal growth in the tx-j
6. Sufrin JR, Finckbeiner S, Oliver CM. Marine-derived mouse model of Wilson disease. Epigenetics 2014; 9:
286-96.
metabolites of S-adenosylmethionine as templates for
22. Shimizu K, Abe M, Yokoyama S, et al. Decreased
new anti-infectives. Mar Drugs 2009; 7: 401-34. activities of S-adenosylmethionine synthetase
isozymes in hereditary hepatitis in Long-Evans rats.
7. Konze JR, Kende H. Interactions of Methionine and Life Sci 1990; 46: 1837-42.
Selenomethionine with Methionine
23. Martinez-Vega R, Partearroyo T, Vallecillo N, Varela-
Adenosyltransferase and Ethylene-generating Moreiras G, Pajares MA, Varela-Nieto I. Long-term
omega-3 fatty acid supplementation prevents
Systems. Plant Physiol 1979; 63: 507-10. expression changes in cochlear homocysteine
metabolism and ameliorates progressive hearing loss
8. Frey PA, Hegeman AD, Ruzicka FJ. The Radical SAM in C57BL/6J mice. J Nutr Biochem 2015; doi:
Superfamily. Crit Rev Biochem Mol Biol 2008; 43: 10.1016/j.jnutbio.2015.07.011.
63-88. 24. Mueller JH. A new sulphur-containing amino acid
isolated from hydrolytic products of protein. J Biol
9. Mato JM, Alvarez L, Ortiz P, Pajares MA. S- Chem 1923; 56: 157-69.
adenosylmethionine synthesis: molecular mechanisms
and clinical implications. Pharmacol Ther 1997; 73: 25. Womack M, Kemmerer KS, Rose WC. The relation of
dietary methionine and cysteine to growth. J Biol
265-80. Chem 1937; 121: 403-10.
10. Aguilar TS, Benevenga NJ, Harper AE. Effect of 26. Pajares MA, Perez-Sala D. Betaine homocysteine S-
dietary methionine level on its metabolism in rats. J methyltransferase: just a regulator of homocysteine
Nutr 1974; 104: 761-71. metabolism? Cell Mol Life Sci 2006; 63: 2792-803.
11. Zeisel SH, Wurtman RJ. Dietary intake of methionine: 27. Szegedi SS, Castro CC, Koutmos M, Garrow TA.
Betaine-homocysteine S-methyltransferase-2 is an S-
Influence of brain S-adenosylmethionine. In: Usdin E, methylmethionine-homocysteine methyltransferase. J
Biol Chem 2008; 283: 8939-45.
Borchardt RT, Creveling CR, Eds. Transmethylation.
28. Chen NC, Yang F, Capecci LM, et al. Regulation of
New York: Elsevier 1979; pp. 59-68. homocysteine metabolism and methylation in human
and mouse tissues. FASEB J 2010; 24: 2804-17.
12. Martinez-Vega R, Garrido F, Partearroyo T, et al. Folic
acid deficiency induces premature hearing loss 29. Mudd SH, Finkelstein JD, Irreverre F, Laster L.
Transsulfuration in mammals. Microassays and tissue
through mechanisms involving cochlear oxidative distributions of three enzymes of the pathway. J Biol
Chem 1965; 240: 4382-92.
stress and impairment of homocysteine metabolism.
30. Finkelstein JD. Metabolic regulatory properties of S-
FASEB J 2015; 29: 418-32. adenosylmethionine and S-adenosylhomocysteine.
Clin Chem Lab Med 2007; 45: 1694-9.
13. Lu SC, Mato JM. S-adenosylmethionine in liver health,
injury, and cancer. Physiol Rev 2012; 92: 1515-42. 31. Ou X, Yang H, Ramani K, et al. Inhibition of human
betaine-homocysteine methyltransferase expression by
14. McCully KS. Vascular pathology of homocysteinemia:
implications for the pathogenesis of arteriosclerosis.
Am J Pathol 1969; 56: 111-28.
15. Ueland PM, Refsum H. Plasma homocysteine, a risk
factor for vascular disease: plasma levels in health,
disease, and drug therapy. J Lab Clin Med 1989; 114:
473-501.
16. Hooijmans CR, Blom HJ, Oppenraaij-Emmerzaal D,
Ritskes-Hoitinga M, Kiliaan AJ. S-
adenosylmethionine and S-adenosylhomocysteine
levels in the aging brain of APP/PS1 Alzheimer mice.
Neurol Sci 2009; 30: 439-45.
17. Panza F, Frisardi V, Capurso C, et al. Possible role of
S-adenosylmethionine, S-adenosylhomocysteine, and
polyunsaturated fatty acids in predementia syndromes
@Real Academia Nacional de Farmacia. Spain 243