Page 16 - 81_02
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Problems associated with the emission of pharmaceutical products to the environment

57. Grenier, J-F. Maturity of Global Pharma Market            Ternes N. Consumption and Ocurrence. Human
confirmed. PharmaExpand Exchange. Disponible en:              Pharmaceuticals, Hormones and Fragances. In: Ternes T.
(pharmaexpand.com/wordpress/?p=223) 2013.                     y Joss A., Eds. The challenge of micropollutants in urban
                                                              water management IWA Pub. Londres 2006.
58. KNAPPE project. Knowledge and Need Assessment
on Pharmaceuticals Products in Environmental Waters.          73. Lienert J, Bürki T, y Escher BL. Reducing
Final report. 2008.                                           micropollutants with source control: substance flow
                                                              analysis of 212 pharmaceuticals in faeces and urine. Water
59. Boxall, AB. et al. Pharmaceuticals and Personal Care      Sci. Technol. 2007; 56: 87-96.
Products in the Environment: What Are the Big
Questions? Environm, Health Perspectives, 2012; 120, 9:       74. Celiz M D, Tso J. y Aga DS. Pharmaceutical
1221-1229.                                                    metabolites in the environment: Analytical challenges and
                                                              ecological risks. Environm. Toxicol. Chem. 2009; 28, 12:
60. Alder A, Bruchet A, Carballa M., Clara M, Joss A,         2473-2484.
Löffler D, McArdell C., Miksch K, Oimil F, Tuhkanen T y
Ternes N. Consumption and Ocurrence. Human                    75. Walgren, JL Mitchell MD y Thompson DC. Role of
Pharmaceuticals, Hormones and Fragances. In: Ternes T. y      metabolism in drug induced idiosyncratic hepatoxicity.
Joss A, Eds. The challenge of micropollutants in urban        Cri. Rev. Toxicol.2005; 35: 325-361.
water management IWA Pub. Londres 2006.
                                                              76. Nalec-Jawecki, G. Evaluation of the in vitro
61. BIO Intelligence Service. Study on the Environmentl       biotransformation of fluexetine with HPLC, mass
risks of medicinal products. Executive Agency for Health      spectrometry and ecotoxicological tests. Chemosphere,
and Consumers. Paris 2013.                                    2007; 70: 29-35.

62. Simó Miñana J. Utilización de medicamentos en             77. European Environmental Agency. (EEA).
España y Europa. Atención Primaria, 2012; 44, 6: 335-         Pharmaceuticals in the Environment. Results of an EEA
347.                                                          workshop. Copenhagen. 2010.

63. Le Pen C, Lemasson H. y Roulliere-Lelilec C. La           78. Roig B. Ed. Pharmaceuticals in the Environment.
consommation medicamenteuse dans 5 pays eropeén: une          Current knowledge and need assessment to reduce
reévaluaation. LEE (Les entreprises du medicament).Paris      presence and impact. IWA Pub. Londres 2010.
2007.
                                                              79. Boxall AB. Fate of veterinary Medicines Applied to
64. Kümmerer K. Pharmaceuticals in the Environment.           Soils. En: Kümmerer K. Ed. Pharmaceuticals in the
Sources, Fate, Effects and Risks. Springer-Verlag. Berlin.    Environenment. Sources, fate, Effects and Risks. Springer-
2nd. ed. 2004, 3rd ed. 2008.                                  Verlag. Berlin, 2008.

65. BIO Intelligence Service. Study on the Environmentl       80. Cabello FC. Heavy use of prophylactic antibiotics in
risks of medicinal products. Executive Agency for Health      aquaculture: a growing problem for human and animal
and Consumers. Paris 2013.                                    health and for environment. Environ. Microbiol.2006; 8:
                                                              1137-1144.
66. Sacher F, Ehmann M, Gabriel S. Graf C. y Brauch HJ.
Pharmaceutical residues in the river Rhine-results of a one-  81. Scottish Environment Protection Agency (SEPA). The
decade monitoring programme. J. Environm.                     occurrence of chemical residues in sediments in Loch
Monit.2008;,10: 664-670.                                      Erisort, Loch Roag and Loch a Chain Baihn. Sea Loch
                                                              Survey, 2012.
67. Bernard M, Arnols M, Edder P y Ortelli D.
Micropollutants in the wáter of the river Rhône-2006          82. Sadezky A, Löffler D, Schlüsener M., Roig B. y
Campaign. Rapp. Comm. Int. prot. Eaux Léman contre            Ternes T. Real situation: Occurrence on the main
pollut. Campagne 2006: 163-172. 2007.                         investiged PPs in water bodies. En: Roig B, Ed.
                                                              Pharmaceuticals in the Environment. IWA Pub. Londres,
68. Larsson JD, de Pedro C y Paxeus N. Effluent from          2010.
drug manufactures contains extremely high level of
pharmaceuticals. J. Hazard. Mater. 2007; 148: 751-755.        83. Airis AZ , Shamsuddin AS y Praveena SM.
                                                              Occurrence of 17a-ethynylstradiol (EE2) in the
69. Fick J, Söderström H, Lindberg RH, Phan C, Tysklind       environment and effect on exposed biota: a review. Env.
M. y Larsson JD. Contamination of surface, ground and         Int.2014; 69: 104-119.
drinking water from pharmaceutical production.
Environm. Toxicol. Chem.2009; 28: 2522-2527.                  84. Zabczynski S, Buntner D, Miksc K. y Roig B.
                                                              Performance of conventional treatment processes of the
70. Daughton CG y Ruhoy IS. Environmental Footprint of        most resistant PPs. En: Roig B, Ed. Pharmaceuticals in the
Pharmaceuticals- The Significance of Factors Beyond           Environment . AGA Pub. Londres, 2010.
Direct Excrection to Sewers. Environm. Toxicol.
Chem.2009; 28, 12: 2495-2521.                                 85. Sadezky A, Löffler D, Schlüsener M, Roig B. y Ternes
                                                              T. Real situation: Occurrence on the main investiged PPs
71. BIO Intelligence Service. Study on the Environmentl       in water bodies. En: Roig B. Ed. Pharmaceuticals in the
risks of medicinal products. Executive Agency for Health      Environment. IWA Pub. Londres, 2010.
and Consumers. Paris 2013.
                                                              86. Sadezky, A., Löffler,D., Schlüsener,M., Roig, B. y
72. Alder A, Bruchet A, Carballa M, Clara M, Joss A.,         Ternes, T. Real situation: Occurrence on the main
Löffler D, McArdell C, Miksch K, Oimil F, Tuhkanen T y

@Real Academia Nacional de Farmacia. Spain                                           99
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