Page 47 - 78_04
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BASES	
  MOLECULARES	
  DE	
  LA	
  ESQUIZOFRENIA	
  

	
  

     60. Zafra,	
   F.;	
   Aragón,	
   C.;	
   Olivares,	
   L.;	
   Danbolt,	
   N.C.;	
   Giménez,	
   C.	
   &	
   Storm-­-Mathisen,	
   J.	
   (1995)	
  
           Glycine	
   transporters	
   are	
   differentially	
   expressed	
   among	
   CNS	
   cells.	
   Journal	
   of	
  
           Neuroscience	
  15,	
  3952-­-3969.	
  

     61. Zafra,	
   F.;	
   Gomeza,	
   J.;	
   Olivares,	
   L.;	
   Aragón,	
   C.	
   &	
   Giménez,	
   C.	
   (1995)	
   Regional	
   distribution	
  
           and	
  developmental	
  variation	
  of	
  the	
  glycine	
  transporters	
  GLYT1	
  and	
  GLYT2	
  in	
  the	
  rat	
  CNS.	
  
           European	
  Journal	
  of	
  Neuroscience	
  7,	
  1342-­-1352.	
  

     62. Cubelos,	
  B.;	
  Giménez,	
  C.	
  &	
  Zafra,	
  F.	
  (2005)	
  Localization	
  of	
  the	
  GLYT1	
  glycine	
  transporter	
  at	
  
           glutamatergic	
  synapses	
  in	
  the	
  rat	
  brain.	
  Cerebral	
  Cortex	
  15,	
  448-­-459.	
  

     63. Cubelos,	
  B.;	
  González-­-González,	
  I.M.;	
  Giménez,	
  C.	
  &	
  Zafra,	
  F.	
  (2005)	
  The	
  scaffolding	
  protein	
  
           PSD-­-95	
   interacts	
   with	
   the	
   glycine	
   transporter	
   GLYT1	
   and	
   impairs	
   its	
   internalization.	
  
           Journal	
  of	
  Neurochemistry	
  95,	
  1047-­-1058.	
  

     64. González-­-González,	
  I.	
  M.;	
  García-­-Tardón,	
  N.;	
  Cubelos,	
  B.;	
  Giménez,	
  C.	
  &	
  Zafra,	
  F.	
  (2008)	
  The	
  
           glutamate	
   transporter	
   GLT1b	
   interacts	
   with	
   the	
   scaffold	
   protein	
   PSD-­-95.	
   Journal	
   of	
  
           Neurochemistry	
  105,	
  1834-­-1848.	
  

     65. Krystal,	
   J.H.;	
   Anand,	
   A.	
   &	
   Moghaddam,	
   B.	
   (2002)	
   Effects	
   of	
   NMDA	
   receptor	
  
           antagonists:implications	
   for	
   the	
   pathophysiology	
   of	
   schizophrenia.	
   Archives	
   of	
   General	
  
           Psychiatry	
  59,	
  663-­-664.	
  	
  

     66. Abi-­-Saab,	
   W.M.;	
   D'Souza,	
   D.	
   C.;	
   Moghaddam,	
   B.	
   &	
   Krystal,	
   J.	
   H.	
   (1998)	
   The	
   NMDA	
  
           antagonist	
   model	
   for	
   schizophrenia:	
   promise	
   and	
   pitfalls.	
   Pharmacopsychiatry	
   31	
  
           Suppl2,104-­-109.	
  	
  

     67. Krystal,	
  J.H.;	
  Karper,	
  L.	
  P.;	
  Seibyl,	
  J.	
  P.;	
  Freeman,	
  G.	
  K.;	
  Delaney,	
  R.;	
  Bremner,	
  J.	
  D.;	
  Heninger,	
  
           G.	
  R.;	
  Bowers,	
  M.	
  B.	
  Jr.	
  &	
  Charney,	
  D.	
  S.	
  (1994)	
  Subanesthetic	
  effects	
  of	
  the	
  noncompetitive	
  
           NMDA	
   antagonist,	
   ketamine,	
   in	
   humans.	
   Psychotomimetic,	
   perceptual,	
   cognitive,	
   and	
  
           neuroendocrine	
  responses.	
  Archives	
  of	
  General	
  Psychiatry	
  51,	
  199-­-214.	
  

     68. Sur,	
   C.	
   &	
   Kinney,	
   G.	
   G.	
   (2007)	
   Glycine	
   transporter	
   1	
   inhibitors	
   and	
   modulation	
   of	
   NMDA	
  
           receptor-­-mediated	
  excitatory	
  neurotransmission.	
  Current	
  Drug	
  Target	
  8,	
  643-­-649.	
  

     69. Lindsley,	
  C.	
  W.;	
  Zhao,	
  Z.;	
  Leister,	
  W.	
  H.;	
  O'Brien,	
  J.;	
  Lemaire,	
  W.;	
  Williams.	
  D.	
  L.	
  Jr.;	
  Chen,	
  T.	
  
           B.;	
  Chang,	
  R,	
  S.;	
  Burno,	
  M.;	
  Jacobson,	
  M.	
  A.;	
  Sur,	
  C.;	
  Kinney,	
  G.	
  G.;	
  Pettibone,	
  D.	
  J.;	
  Tiller,	
  P.	
  R.;	
  
           Smith,	
  S.;	
  Tsou,	
  N.	
  N.;	
  Duggan,	
  M.	
  E.,	
  Conn,	
  P.	
  J.	
  &	
  Hartman,	
  G.	
  D.	
  (2006)	
  Design,	
  synthesis,	
  
           and	
  in	
  vivo	
  efficacy	
  of	
  glycine	
  transporter-­-1	
  (GlyT1)	
  inhibitors	
  derived	
  from	
  a	
  series	
  of[4-­-
           phenyl-­-1-­-(propylsulfonyl)piperidin-­-4-­-yl]methylbenzamides.	
   Chemical	
   	
   Medicine	
   	
   8,	
   807-­-
           811.	
  

     70. Rogers,	
  B.	
  N.	
  &	
  Schmidt,	
  C.	
  J.	
  (2006)	
  Novel	
  approaches	
  for	
  the	
  treatment	
  of	
  schizophrenia.	
  
           Annual	
  Reports	
  in	
  Medicinal	
  Chemistry	
  41,	
  1-­-21.	
  

     71. Sur,	
   C.	
   &	
   Kinney,	
   G.	
   (2007)	
   Glycine	
   transporter	
   1	
   inhibitors	
   and	
   modulation	
   of	
   NMDA	
  
           receptor-­-mediated	
  excitatory	
  neurotransmission.	
  Current	
  Drug	
  Targets	
  8,	
  643-­-649.	
  

     72. Dohi,	
  T.;	
  Morita,	
  K.;	
  Kitiyama,	
  T.;	
  Motoyama,	
  N.	
  &	
  Morioka,	
  N.	
  (2009)	
  Glycine	
  transporter	
  
           inhibitors	
   as	
   a	
   novel	
   drug	
   discovery	
   strategy	
   for	
   neuropathic	
   pain.	
   Pharmacology	
   and	
  
           Terapeuthics	
  123,	
  54-­-79.	
  

	
  

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