Page 64 - 76_02

ANDRÉS R. ALCÁNTARA LEÓN Y COLS. AN. R. ACAD. NAC. FARM.

51. Sit, S., et al. (1990) Synthesis, biological profile, and quantitative structure-
activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme
A reductase inhibitors. J. Med. Chem. 33: 2982.

52. Patel, R. N., et al. (1993) Enantioselective microbial reduction of 3,5-dioxo-6-
(benzyloxy)hexanoic acid, ethyl ester. Enzyme Microb. Technol. 15: 1014.

53. Patel, R. N., et al. (1992) Enantioseleetive enzymic acetylation of racemic
[4-[4",6$E]]-6-[4,4-bis[4-fluorofenil]3-(1-metil-1H-tetrazol-5-il)-1,3-butadienil]
tetrahidro- 4-hidroxi-2H-piren.2.ona. Appl. Microbiol. Biotechnol. 38: 56.

54. Steiger, A.; Pyun, H. & Coates, R. (1992) Synthesis and characterization of
aza analog inhibitors of squalene and geranylgeranyl diphosphate synthases.
J. Org. Chem. 57: 3444.

55. Lawrence, M.; Biller, S. & Fryszman, O. (1995) Preparation of -phosphonosul-
finic squalene synthetase inhibitors. US. Patent 5447922.

56. Patel, R. N., et al. (1997) Stereoselective acetylation of 1-(hydroxy)-4-(3 phe-
nyl)butyl]phosphonic acid diethyl ester. Tetrohedron Asymmetry. 8: 1055.

57. Nakane, M. (1987) Preparation and formulation of 7-oxabicycloheptane substi-
tuted sulfonamide prostaglandin analog useful in treatment of thrombolic disea-
se. US. Patent 4,663,336.

58. Ford-Hutchinson, A. W. (1991) Innovations in drug research: inhibitors of
thromhoxane and leukotrienes. Clin. Exper. Allergy. 21: 272.

59. Das, J., et al. (1987) Synthesis of optically 7-oxabicyclo [2.2.l]heptanes and
assignmens of absolute configuration. Synthesis. 12: 1100.

60. Patel, R. N., et al. (1992) Stereoselective microbial enzymatic oxidation of
(exo,exo)-7-oxabicyclo [2,2,1] heptane-2,3-dimethanol to the corresponding
chiral lactol and lactone. Enzyme Microb. Technol. 14: 778.

61. Patel, R. N., et al. (1992) Stereoselective enzymic hydrolysis of (exo,exo)-7-
oxabicyclo[2.2.1] heptane-2.3-dimethanol diacetate ester in a hiphasic system.
Appl. Microbiol. Biotechnol. 37: 180.

62. Edwards, O. & Weston, A. H. (1990) Structure-activity relationships of K+
channel openers. Trends Pharmacol. Sci. 11: 417-422.

63. Robertson, D. W. & Steinberg, M. I. (1989) Potassium channel openers: new
biological probes. Ann. Med. Chem. 24: 91.

64. Hamilton, T. C. & Weston, A. H. (1989) Cromakalim, nicorandil and pinacidil:
novel drugs which open potassium channels in smooth muscle. Gen. Pharmac.
20: 1.

65. Ashwood, V. A., et al. (1986) Synthesis and antihypertensive activity of 4-
(cyclic amido)-2H-1-benzopyrans. J. Med. Chem. 29: 2194.

66. Bergmann, R.; Eierniann, V. & Gericke, R. J. (1990) 4-Heterocyclyloxy-2H-l-
benzopyran potassium channel activators. J. Med. Chem. 33: 2759.

67. Patel, R. N., et al. (1994) Stereoselective epoxidation of 2, 2-dimethyl-2H-1-
benzopyran-6-carbonitrile. Bioorg. Med. Chem. 2: 535.

68. Patel, R. N., et al. (1995) Stereoselective acetylation of 3,4-dihydro-3,4-di-
hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile. Tetrahedron Asymmetry.
6: 123.

69. Archelas, A. & Furstoss, R. (1999) Biocatalytic approaches for the synhesis of
enantiopure epoxides. Top. Curr. Chem. 200: 159.

302