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An. R. Acad. Nac. Farm., 2006, 72: 37-47

Artículo original

Mitochondrial lineages distribution in the
Spanish population: anticipating association

studies

Recibido el 6 de febrero de 2006

YAHYA DAHMANY 1, ANA MARCUELLO 1, FRANCISCO JOSÉ
MONTIEL-SOSA 1, 2, JULIO MONTOYA 1, CARMEN DÍEZ-
SÁNCHEZ 1, MANUEL JOSÉ LÓPEZ-PÉREZ 1, 3, *,
EDUARDO RUIZ-PESINI 1, 3
1 Departamento de Bioquímica, Biología Molecular y Celular.
Universidad de Zaragoza. Zaragoza.
2 Present address: Departamento de Ciencias Biológicas.
Facultad de Estudios Superiores Cuautitlan.
Universidad Nacional Autónoma de México.
3 These two authors have the same participation in the work.

SUMMARY

The genetic variation in mtDNA has been widely used to give a maternal genetic
perspective of the human demographic history. Here, we have studied this
variability in 686 samples coming from the Centre and North of Spain. These
results showed that haplogroup frequencies were similar to other Spanish studies
and European populations. Haplogroups from the HV lineage were over-represented
in the Spanish population. A deeper analysis of the mitochondrial haplogroup U
showed differences with Northern Europe populations. The frequencies of
haplogroups found give them high valour when experimental design for
mitochondrial disorder studies in population is planted. In addition, the use of
these data is also important for forensic studies.

* Corresponding author: Dr. Manuel José López-Pérez. Departamento de Bioquími-
ca, Biología Molecular y Celular. Universidad de Zaragoza. 50013 Zaragoza. Spain.
Phone: 976-761642. Fax: 976-761612. Email: lopezper@unizar.es

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