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VOL. 72 (1), 27-36, 2006 ANTIAPOPTOTIC PROTEINS BCL2 AND BCLX...
high fraction of apoptotic cells which were absent in the Kbcl2v and
KbclX cells (Fig. 3B), thus confirming the result observed through
the annexin V assay.
FIGURE 2. (A) Inhibition of DNA synthesis measured by 3H-thymidine incorporation
in K562, Kbcl2v and KbclX treated with 0.5 µM and 2.5 µM imatinib for 48 h and
72 h as indicated at the bottom of the graph. (B) Inhibition of DNA synthesis in
K562, Kbcl2v and KbclX treated with 0.5 mM busulfan (BU), 0.5 mM hydroxyurea
(HU) and 2000 UI/ mL of IFNa for 72 h. The data obtained with 0.5 µM imatinib is
included for comparison.
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