Page 42 - 69_03

N. LÓPEZ MORATALLA ANAL. REAL ACAD. NAL. FARM.

ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin
Invest 107, 1395–1402; LAGASSE E, CONNORS H, AL-DHALIMY M ET AL.
(2000) Purified hematopoietic stem cells can differentiate into hepatocytes in
vivo. Nat Med 6, 1229–1234; KRAUSE DS, THEISE ND, COLLECTOR MI ET AL.
(2001) Multi-organ, multi-lineage engraftment by a single bone marrow-

derived stem cell. Cell 105, 369–377; GALLI R, BORELLO U, GRITTI A ET AL.
(2000) Skeletal myogenic potential of human and mouse neural stem cells. Nat
Neurosci 3, 986–991; CLARKE DL, JOHANSSON CB, WILBERTZ J ET AL. (2000)
Generalized potential of adult neural stem cells. Science 288, 1660–1663;
ZULESWSKI H, ABRAHAM EJ, GERLACH MJ ET AL. (2001) Multipotential nestin-

positive stem cells isolated from adult pancreatic islets differentiate ex vivo into

pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521-33.
(6) Cfr especialmente los trabajos de CATHERINE M. VERFAILLIE. ENTRE OTROS:

REYES M, LUND T, LENVIK T, AGUIAR D, KOODIE L, VERFAILLIE CM. (2001)

Purification and ex vivo expansion of postnatal human marrow mesodermal

progenitor cells. Blood. 98, 2615-2625; Overturf K, Al-Dhalimy M, Tanguay R,

et al. (2002) Origin of endothelial progenitors in human post-natal bone mar-

row. J Clin Invest. 109, 337-346.
(7) PALMIERI S, PETER W, HESS H ET AL. (1994) Oct-4 transcription factor is dif-

ferentially expressed in the mouse during establishment o the first two extraem-

bryonic cell lineages involved in implantation. Developmental Biology 166,
259-267

(8) ABDEL-RAHMAN B, FIDDLER M, RAPPOLEE D ET AL. (1995) Expression of

transcription regulating genes in human preimplantation embryos. Human
Reproduction 10, 2787-2792.
(9) HANSIS C, GRIFO JAS, KREY LC (2000) Oct-4 expression in inner cell mass and
trophectoderm of human blastocysts. Molecular Human Reproduction 6, 999-
1004.

(10) REUBINOFF BE, PERA MF, FONG CY ET AL. (2000) Embryonic stem cell lines

from human blastocysts: somatic differentiation in vitro. Nature Biotechnology
18, 399-404.

(11) SPRADLING A, DRUMMOND-BARBOSA D, KAI T (2001) Stem cells find their

niche Nature 414, 98-104.
(12) TSAI RVL, KITTAPPA R, MCKAY RDG (2002) Plasticity, niches, and the use of

stem cells. Develop Cell 2, 707-712.
(13) JIANG Y, JAHAGIRDAR BN, REINHARDT RE, SCHWARTZ LR, KEENE CD, ORTIZ-

GONZALEZ XR, REYES M, . LENVIK T, LUND T, BLACKSTAD M, DU J, ALDRICH

S, LISBERG A, LOW WC, LARGAESPADA DA, VERFAILLIE CM (2002) Pluripo-

tency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-
49.

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