Page 62 - 68_03
P. 62
VOL. 68 (3), ANAL. REAL ACAD. NAC. FARM
and its target threonine-410 in the activation loop of protein kinase C-zeta.
Mol.Endocrinol. 13:1766-1772.
(25) VALVERDE, A.M., LORENZO, M., NAVARRO, P., MUR, C. AND BENITO, M. (2000)
Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes
in an Akt-independent and protein kinase C zeta-dependent manner. FEBS Lett.
472:153-158.
(26) VALVERDE, A.M., TERUEL, T., NAVARRO, P., BENITO, M. AND LORENZO, M.
(1998) Tumor necrosis factor-alfa causes insulin receptor substrate-2-mediated
insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipo-
cytes. Endocrinology 139:1229-1238.
(27) SMITH, U., CARVALHO, E., MOSIALOU, E., BEGUINOT, F., FORMISANO, P. AND
RONDINONE, C. (2000) PKB inhibition prevents the stimulatory effect of insulin
on glucose transport and protein translocation but not the antilipolytic effect in rat
adipocytes. Biochem. Biophys.Res.Commun. 268: 315-320.
(28) HERNANDEZ, R., TERUEL, T. AND LORENZO, M. (2001) Akt mediates insulin in-
duction of glucose uptake and up-regulation of GLUT4 gene expression in brown
adipocytes. FEBS Lett 494:225-231.
(29) POWELL, K.A., CAMPBELL, L.C., TAVARE, J.M., LEADER, D.P., WAKEFIELD, J.A.
AND GOULD, G.W. (1999) Trafficking of Glut4-green fluorescent protein chi-
maeras in 3T3-L1 adipocytes suggests distinct internalization mechanisms regu-
lating cell surface glut4 levels. Biochem.J. 344:535-543.
(30) LONG, S.D. AND PEKALA, P.H. (1996) Lipid mediators of insulin resistance: ce-
ramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipo-
cytes. Biochem.J. 319:179-184.
(31) TERUEL, T., HERNANDEZ, R. AND LORENZO, M. (2001) Ceramide mediates insulin
resistance by tumor necrosis factor-alfa in brown adipocytes by maintaining Akt
in an inactive dephosphorylated state. Diabetes 50:2563-2571.
(32) JAIN, R., POLICE, S., PHELPS, K. AND PEKALA, P.H. (1999) Tumour necrosis fac-
tor-alfa regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs)
alfa and beta and determines the occupation of the C/EBP site in the promoter of
the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes. Biochem.J.
338:737-743.
(33) SALINAS, M., LOPEZ-VALDALISO, R., MARTIN, D., ALVAREZ, A. AND CUADRADO,
A. (2000) Inhibition of PKB/Akt1 by C2-ceramide involves activation of cera-
mide-activated protein phosphatase in PC12 cells. Mol.Cell Neurosci 15:156-169.
59