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VOL. 68 (3),  ANAL. REAL ACAD. NAC. FARM

        and its target threonine-410 in the activation loop of protein kinase C-zeta.
        Mol.Endocrinol. 13:1766-1772.

(25) VALVERDE, A.M., LORENZO, M., NAVARRO, P., MUR, C. AND BENITO, M. (2000)
        Okadaic acid inhibits insulin-induced glucose transport in fetal brown adipocytes
        in an Akt-independent and protein kinase C zeta-dependent manner. FEBS Lett.
        472:153-158.

(26) VALVERDE, A.M., TERUEL, T., NAVARRO, P., BENITO, M. AND LORENZO, M.
        (1998) Tumor necrosis factor-alfa causes insulin receptor substrate-2-mediated
        insulin resistance and inhibits insulin-induced adipogenesis in fetal brown adipo-
        cytes. Endocrinology 139:1229-1238.

(27) SMITH, U., CARVALHO, E., MOSIALOU, E., BEGUINOT, F., FORMISANO, P. AND
        RONDINONE, C. (2000) PKB inhibition prevents the stimulatory effect of insulin
        on glucose transport and protein translocation but not the antilipolytic effect in rat
        adipocytes. Biochem. Biophys.Res.Commun. 268: 315-320.

(28) HERNANDEZ, R., TERUEL, T. AND LORENZO, M. (2001) Akt mediates insulin in-
        duction of glucose uptake and up-regulation of GLUT4 gene expression in brown
        adipocytes. FEBS Lett 494:225-231.

(29) POWELL, K.A., CAMPBELL, L.C., TAVARE, J.M., LEADER, D.P., WAKEFIELD, J.A.
        AND GOULD, G.W. (1999) Trafficking of Glut4-green fluorescent protein chi-
        maeras in 3T3-L1 adipocytes suggests distinct internalization mechanisms regu-
        lating cell surface glut4 levels. Biochem.J. 344:535-543.

(30) LONG, S.D. AND PEKALA, P.H. (1996) Lipid mediators of insulin resistance: ce-
        ramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipo-
        cytes. Biochem.J. 319:179-184.

(31) TERUEL, T., HERNANDEZ, R. AND LORENZO, M. (2001) Ceramide mediates insulin
        resistance by tumor necrosis factor-alfa in brown adipocytes by maintaining Akt
        in an inactive dephosphorylated state. Diabetes 50:2563-2571.

(32) JAIN, R., POLICE, S., PHELPS, K. AND PEKALA, P.H. (1999) Tumour necrosis fac-
        tor-alfa regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs)
        alfa and beta and determines the occupation of the C/EBP site in the promoter of
        the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes. Biochem.J.
        338:737-743.

(33) SALINAS, M., LOPEZ-VALDALISO, R., MARTIN, D., ALVAREZ, A. AND CUADRADO,
        A. (2000) Inhibition of PKB/Akt1 by C2-ceramide involves activation of cera-
        mide-activated protein phosphatase in PC12 cells. Mol.Cell Neurosci 15:156-169.

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