Page 40 - 66_03

PALOMA NAVARRO Y COLS. ANAL. REAL ACAD. FARM.

(31) FERRARI G AND GREENE L (1994) Proliferative inhibition by dominant-negative Ras
rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO
J 13, 5922-5928.

(32) YAO R AND COOPER GM (1995) Requirement for phosphatidylinositol-3 kinase in
the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.

(33) MCCARTHY NJ, WHYTE MKB, GILBERT CS AND EVAN GI (1997) Inhibition of
Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes,
DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 136, 215-227.

(34) YAMAMOTO AM, ELOY L, BACH JF AND GARCHON HJ (1998) N-terminus
cleavage of bcl-2 by a novel cellular non-ICE cysteine proteinase. Leukemia 12,
1467-1472.

(35) GREEN DR AND REED JC (1998) Mitochondria and apoptosis. Science 281, 1309-
1312.

(36) GREEN D AND KROEMER G (1998) The central executioners of apoptosis:
caspases or mitochondria? Trends Cell Biol 8, 267-271.

(37) KAUFFMANN-ZEH A, RODRIGUEZ-VICIANA P, ULRICH E, GILBERT C, COFFER P,
DOWNWARD J AND EVAN G (1997) Suppression of c-Myc-induced apoptosis by
Ras signalling through PI(3)K and PKB. Nature 385, 544-548.

(38) LIU HS, CHEN CY, LEE CH AND CHOU YI (1998) Selective activation of
oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells. Br J Cancer 11, 1777-
1786.

(39) FERNANDEZ-SARABIA MJ AND BISCHOFF JR (1993) Bcl-2 associates with the ras-
related protein R-Ras p23. Nature 366, 274-275.

(40) PARRIZAS M, SALTIEL AR AND LEROITH (1997) Insulin-like growth factor 1
inhibits apoptosis using the phosphatidylinositol 3´-kinase and Mitogen-activated
protein kinase pathways. J Biol Chem 272, 154-161.

(41) HARRINGTON EA, BENNETT MR, FANIDI A AND EVAN GI (1994) c-Myc-induced
apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 13, 3286-3295.

(42) FABREGAT I, SÁNCHEZ A, ALVAREZ AM, NAKAMURA T AND BENITO M (1996)
Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis
induced by transforming growth factor-beta in fetal hepatocytes in primary culture.
FEBS Letters 384, 14-18.

(43) VALVERDE AM, TERUEL T, LORENZO M AND BENITO M (1996) Involvement of Raf-
1 kinase and protein kinase C ] in Insulin-like growth factor I-induced brown
adipocyte mitogenic signaling cascades: inhibition by cyclic adenosine 3',5'-
monophosphate. Endocrinology 137, 3832-3841.

(44) DUDEK H, DATTA SR, FRANKE TF, BIRNBAUM MJ, YAO R, COOPER GM, SEGAL
RA, KAPLAN DR AND GREENBERG ME (1997) Regulation of neuronal survival by
the serine-threonine protein kinase Akt. Science 275, 661-664.

(45) KULIK G, KLIPPEL A AND WEBER MJ (1997) Antiapoptotic signalling by the
Insulin-like Growth Factor I Receptor, phosphatidylinositol 3-kinase, and Akt.
Mol Cell Biol 17, 1595-1606.

22