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Curcumin and curcuminoids: chemistry, structural studies and biological properties

     transfer in curcumin. J Mol Struct Theochem 2004;            induced apoptosis by bcl-2-mitochondria-ROS-iNOS
     685: 111-6.                                                  pathway. Apoptosis 2006; 11: 943-53.

112.Masuda T, Hidaka K, Shinohara A, Maekawa T,              125.Braidy N, Grant R, Adams S, Guillemin GJ.
     Takeda Y, Yamaguchi H. Chemical studies on                   Neuroprotective effects of naturally occurring
     antioxidant mechanism of curcuminoid: analysis of            polyphenols on quinolinic acid-induced excitotoxicity
     radical reaction products from curcumin. J Agric Food        in human neurons. FEBS J 2010; 277: 368-82.
     Chem 1999; 47: 71-7.
                                                             126.Yu SY, Zhang M, Luo J, Zhang L, Li G. Curcumin
113.Weber WM, Hunsaker LA, Abcouwer SF, Deck LM,                  ameliorates memory deficits via neuronal nitric oxide
     Vander Jagt DL. Antioxidant activities of curcumin           synthase in aged mice. Prog Neuropsychopharmacol
     and related enones. Bioorg Med Chem 2005; 13:                Biol Psych 2013; 45: 47-53.
     3811-20.
                                                             127.Egan ME, Pearson M, Weiner SA, Rajendran V,
114.Cao YK, Li HJ, Song ZF, Li Y, Huai QY. Synthesis              Rubin D, Glöckner-Pagel J, Canny S, Du K, Lukacs
     and biological evaluation of novel curcuminoid               GL, Caplan MJ. Curcumin, a major constituent of
     derivatives. Molecules 2014; 19: 16349-72.                   turmeric, corrects cystic fibrosis defects. Science
                                                                  2004; 304: 600-2.
115.Jayaprakasha GK, Rao LJ, Sakariah KK. Antioxidant
     activities of curcumin, demethoxycurcumin and           128.Pabon HJJ. A synthesis of curcumin and related
     bisdemethoxycurcumin. Food Chem 2006; 98: 720-4.             compounds. Rec Trav Chim Pays-Bas 1964; 83: 379-
                                                                  86.
116.Jacob A, Wu R, Zhou M, Wang P. Mechanism of the
     anti-inflammatory effect of curcumin: PPAR-?            129.Gadad BSG, Subramanya PK, Pullabhatla S,
     activation. PPAR Res 2007; 89369: 1-5.                       Shantharam IS, Rao KS. Curcumin-glucoside, a novel
                                                                  synthetic derivative of curcumin, inhibits a-synuclein
117.Seely KA, Levi MS, Prather PL. The dietary                    oligomer formation: relevance to Parkinson's disease.
     polyphenols trans-resveratrol and curcumin selectively       Curr Pharm Des 2012; 18: 76-84.
     bind human CB1 cannabinoid receptors with
     nanomolar affinities and function as                    130.Arezzini B, Ferrali M, Ferrari E, Grandi R, Monti S,
     antagonists/inverse agonists. J Pharmacol Exp Ther           Saladini M. Glycosyl-curcuminoids as potential new
     2009; 330: 31-9.                                             chelating agents in iron overload chelation therapy.
                                                                  Eur J Inorg Chem 2004; 646-52.
118. Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K.
     Effect of curcumin on inflammation and oxidative        131.Nabati M, Mahkam M. Synthesis and characterization
     stress in cisplatin-induced experimental                     of novel silyl derivatives of curcumin. Iran Chem
     nephrotoxicity. J Agric Food Chem 2007; 55: 10150-           Commun 2014; 2: 129-36.
     5.
                                                             132.Fadda AA, Badria FA, El-Attar KM. Synthesis and
119.Brouet I, Ohshima H. Curcumin, an anti-tumor                  evaluation of curcumin analogues as cytotoxic agents.
     promoter and anti-inflammatory agent, inhibits               Med Chem Res 2010; 19: 413-30.
     induction of nitric oxide synthase in activated
     macrophages. Biochem Biophys Res Commun 1995;           133.Nichols CE, Youssef D, Harris RG, Jha A.
     206: 533-40.                                                 Microwave-assisted synthesis of curcumin analogs.
                                                                  Arkivoc 2006; 13: 64-72.
120.Chan MMY, Huang HI, Fenton MR, Fong D. In vivo
     inhibition of nitric oxide synthase gene expression by  134.(a) Tønnesen HH, Másson M, Loftsson T. Studies of
     curcumin, a cancer preventive natural product with           curcumin and curcuminoids. XXVII. Cyclodextrin
     anti-inflammatory properties. Biochem Pharmacol              complexation: solubility, chemical and photochemical
     1998; 55: 1955-62.                                           stability. Int J Pharm 2002; 244: 127-35. (b) Yadav
                                                                  VR, Suresk S, Devi K, Yadav S. Effect of
121.Onoda M, Inano H. Effect of curcumin on the                   cyclodextrin complexation of curcumin on its
     production of nitric oxide by cultured rat mammary           solubility and antiangiogenic and antiinflammatory
     gland. Nitric Oxide 2000; 4: 505-15.                         activity in rat colitis model. AAPS PharmSciTech
                                                                  2009; 10: 752-62. (c) Yadav VR, Prasad S,
122.Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park               Kannappan R, Ravindran J, Chaturved MM, Vaahtera
     KK, Lee SS. Molecular mechanisms underlying                  L, Parkkinen J, Aggarwal BB. cyclodextrin-
     chemopreventive activities of anti-inflammatory              complexed curcumin exhibits antiinflammatory and
     phytochemicals: down-regulation of COX-2 and iNOS            antiproliferative activities superior to those of
     through suppression of NF-?B activation. Mutat Res           curcumin through higher cellular uptake. Biochem
     2001; 480-481: 243-68.                                       Pharmacol 2010; 80: 1021-32. (d) Mohan PRK,
                                                                  Sreelakshmi G, Muraleedharan CV, Joseph R. Water
123.Inano H, Onoda M. Role of nitric oxide in radiation-          soluble complexes of curcumin with cyclodextrins:
     induced initiation of mammary tumorigenesis in rats.         Characterization by FT-Raman spectroscopy. Vib
     Nitric Oxide 2003; 8: 144-8.                                 Spectrosc 2012; 62: 77-84. (e) Rachmawati H,
                                                                  Edityaningrum CA, Mauludin R. Molecular inclusion
124.Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH,               complex of curcumin-ß-cyclodextrin nanoparticle to
     Sun SN, Feng JQ, Chen PX. Curcumin protects PC12
     cells against 1-methyl-4-phenylpyridinium ion-

@Real Academia Nacional de Farmacia. Spain                                          309
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