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Krishna
Naik&
col.
Compound
Zone
of
inhibition
in
mm

(MIC
in
µg/mL)

Bacillus
Cereus
Escherichia
coli

Pseudomanas

Staphylococus
aeruginos

aureus

NCCS
2106
NCCS2065
NCCS
2200

NCCS
2079
2.5(37.5)
2.25(40)
2.5(37.5)

IXj
2.75(32.5)
2.75(35)
2.25(37.5)
2.75(35)

IXk
2.5(35)

4.
CONCLUSSION

All
the
novel
compounds
have
demonstrated
moderate
antimicrobial

activity
against
selected
of
fungal
and
bacterial
stains.

5.
REFERENCES

1. Ericsson,
J.M.;
Sherris,
J.C.;
Antibiotic
sensitivity
testing.
Report
of
an
International

Collaborative
Study.
Acta
Pathol
Microbiol
Scand.,
1971;217,
1-­-90

2. Brown,
B.A.;
Wallace
Jr.,
R.J.;

Onyi,
G.O.
Activities
of
clarithromycin
against
eight
slowly

growing
species
of
nontuberculous
mycobacteria,
determined
by
using
a
broth

microdilution
MIC
system.
Antimicrob.
Agents
Chemother.,
1992;
36,
1987-­-1990

3. El-­-Kashef,
H.S.;

Abd-­-Alla,
M.A.;

Bayoumi,
B
E.;

El-­-Timawy,
A.
A.
M.;
Synthesis
and

antibacterial
activity
of
some
new
pyrazolone
dyes.
J.
Chem.
Technol.
Biot.,1983;
33,
294-­-
298

4. Fan,
X.;
Zhang,
X.;
Zhou,
L.;

Keith,
K.A.;

Kernb,
E.
R.;

Torrencea,
P.
F.;

A
pyrimidine-­-
pyrazolone
nucleoside
chimera
with
potent
in
vitro
anti-­-orthopoxvirus
activity.
Bioorg.

Med.
Chem.
Lett.,2006;16,
3224-­-3228

5. Guckian,
K.;

Carter,
M.B.;

Lin,
E.Y.;

Choi,
M.;

Sun,
L.;

Boriack-­-Sjodin,
P.
A.;

Chuaqui,
C.;

Lane
B.;

Cheung,
K.;

Ling,
L.;

Lee,
W.
C.

Pyrazolone
based
TGFbetaR1
kinase
inhibitors.

Bioorg.
Med.
Chem.
Lett.,2010;
20,
326-­-329

6. Jignesh,
P.R.;
Arpita,
B.S.;
Nilesh,
H.P.;

Hemul,
V.P.;

Pradip,
S.P.;
Kashyap,
K.
B.;
Kishor,
R.D.

Synthesis
and
anti-­-tubercular
activity
of
novel
pyrazol-­-5(H)-­-one
derivatives.
Eur.
J.
Chem.,

2011;2,
238-­-242

7. Manojkumar,
P.;

Ravi,
T.K.;
Gopalakrishnan,
S.
Antioxidant
and
antibacterial
studies
of

arylazopyrazoles
and
arylhydrazonopyrazolones
containing
coumarin
moiety.
Eur.
J.
Med.

Chem.,2009;
44,
4690-­-4694

8. Chandrakantha,
B.;
Shetty,
P.;
Nambiyar,
V.;
Isloor,
N.;
Isloor,
A.M.
Synthesis,

characterization
and
biological
activity
of
some
new
1,3,4-­-oxadiazole
bearing
2-­-flouro-­-4-­-
methoxy
phenyl
moiety.
Eur.
J.
Med.
Chem.,2010;
45,
1206-­-1210

9. Farshori,
N.N.;

Banday,
M.R.;

Ahmad,
A.;

Khan,
A
U.;

Rauf,
A.
Synthesis,
characterization,

and
in
vitro
antimicrobial
activities
of
5-­-alkenyl/hydroxyalkenyl-­-2-­-phenylamine-­-1,3,4-­-
oxadiazoles
and
thiadiazoles.
Bioorg.
Med.
Chem.Lett.,2010;
15,
1933-­-1938

10.
Hussain,
A.;
Ajmal,
M.
Synthesis
of
novel
1,3,4-­-oxadiazole
derivatives
and
their
biological

properties.

Acta
Pharm.,
2009;
59,
223-­-233

11.
Rakesh,
S.;
Awani,
K.R.;
Kesari,
A.N.;
Yar,
M.S.

Synthesis
and
biological
evaluation
of
2,5-­-
disubstituted
1,3,4-­-oxadiazole.
Asian
J.
Res.
Chem.,
2009;
2,
34-­-42

12.
Rakesh,
C.;
Anshu,
A.;
Manoj
Kumar,
P.;
Chander
Sharma,
P.;
Sukumar,
M.;

Thengungal
Ravi,

K.Synthesis
of
novel
1,3,4-­-oxadiazole
derivatives
as
potential
antimicrobial
agents.
Acta

Pol.
Pharm.,
2010;
67,
247-­-253

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