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Novel
compounds
containing
1,3,4-­-oxadiazole…

Compound

Table
1.-­-

Antifungal
activity
of
novel
compounds
synthesized.

Zone
of
inhibition
in
mm

(MIC
in
µg/mL)

-­-R
-­-R1
-­-R2
Aspergillus
niger
Candida
albicans

NCCS
1196
NCCS
2106

VIIa
H
CH3
C6H5
2.25
(55)
1.75(52.5)

VIIb
CH3
CH3
C6H5
1.75(45)
1.25(52.5)

VIIc
OCH3
CH3
C6H5
1.5(52.5)
1.5(52.5)

VIId
OC2H5
CH3
C6H5
1.5(47.5)
1.25(50)

VIIe
Cl
CH3
C6H5
1.75(40)

VIIf
Br
CH3
C6H5
1.75(40)
2(120)

VIIg
CH3
CH6C6H5
1.25(52.5)
1.75(42.5)

VIIh
H
CH3
ClC6H4
2(37.5)
1.25(50)

VIIi
H
CH3
OCH3C6H4
1.5(195)
1.75(33.75)

VIIj
H
CH3
NO2C6H4
1.75(41.25)
1.5(>50)

IXa
H
p-­-tolyl
2.5(45)
1.75(41.25)

IXb
H
H
2.25(47.5)
2.25(45)

IXc
H
H
p-­-anisyl
3.5(35)

IXd
H
H
3.25(37.5)
2(45)

IXe
H
H
p-­-fluoro
phenyl
3.25(37.5)
3(37.5)

IXf
H
H
3.75(32.5)
3.5(36.25)

IXg
H
H
p-­-chloro
phenyl
2(47.5)
3(37.5)

IXh
H
H
2(47.5)
3.25(36.25)

IXi
H
H
p-­-bromo
phenyl
3.5(35)
1.75(47.5)

IXj
H
H
3.25(37.5)
2(47.5)

H
H
p-­-nitro
phenyl
3.25(35)

IXk
3.25(35)
3(35)

H
H
diethyl

3.25(32.5)

di
phenyl

morphonilyl

Piperizyinyl

N-­-methyl

piperizine

Table
2.-­-

Antibacterial
activity
of
novel
compounds
synthesized.

Zone
of
inhibition
in
mm

(MIC
in
µg/mL)

Compound

Staphylococus
Bacillus
Cereus
Escherichia
coli

Pseudomanas

aureus

NCCS
2106
NCCS2065
aeruginos

NCCS
2200

NCCS
2079

VIIa
1.5(50)
1.25(52.5)
1.25(52.5)
1.75(45)

VIIb
1.5(50)
1.25(52.5)
1(55)
1.5(50)

VIIc
1(50)
1.25(50)
1(55)
1.25(52.5)

VIId
2(42.5)
1.5(47.5)
1(50)
1.75(47.5)

VIIe
2(31.25)
2.25(35)
2(32.5)

VIIf
1.75(35)
1.5(47.5)
1.25(47.5)

VIIg
1(55)
2(35)
1.5(45)
1.25(60)

VIIh
2(31.25)
1.25(55)
1(60)
1.75(32.5)

VIIi
1(50)
2(36.25)
1.5(40)
1.25(50)

VIIj
1.75(33.75)
1.5(47.5)
1.5(45)
1.75(41.25)

IXa
1.5(52.5)
1.5(38.75)
1.5(60)

IXb
1.75(50)
2(35)
1.25(57.5)
1.25(57.5)

IXc
2.5(36.25)
1.75(57.5)
1.5(55)
2.5(38.75)

IXd
3(35)
1.5(52.5)
2.25(38.75)
2.75(36.25)

IXe
2.5(37.5)
2.75(38.75)
2.25(38.75)
2.25(37.5)

IXf
2.75(36.25)
2.5(38.75)
2(40)
2.5(35)

IXg
1.75(50)
2.75(38.75)
2.5(35)
5(57.5)

IXh
1.75(50)
2.5(38.75)
1.5(57.5)
1.5(55)

IXi
2.5(37.5)
5(60)
2.75(35)

2(52.5)
2.5(37.5)

1.75(50)
211

3(35)