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José
María
Rojo,
Pilar
Portolés

Multiple
sclerosis

MS

mTOR

Mechanistic
Target
of
Rapamycin

mTORC1
Complex
of
mTOR
containing
Raptor

mTORC2
Complex
of
mTOR
containing
Rictor

NFAT

Nuclear
factor
of
activated
T-­-cells

NF-­-?B

Nuclear
factor
?-­-light-­-chain-­-enhancer
of
activated
B
cells

NK

Natural
killer
lymphocytes

S6K

p70
S6
kinase

PD-­-1

Programmed
death-­-1,
CD279

PDGF

Platelet-­-derived
growth
factor

PDK1

Phosphoinositide-­-dependent
kinase
1

PGE2

Prostaglandin
E2

PH

Pleckstrin
homology
domain

PIKK

PI3K-­-like
protein
kinases

PI3K

Phosphoinositide-­-3
kinases
(PI3Ks)

PKC?
Protein
kinase
?

PKB

Protein
kinase
B

PLC?
Phospholipase
C
?

PROPPIN
ß-­-propeller
that
bind
phosphoinositide
species

PTEN

Phosphatase
and
Tensin
Homologue

PtdInsP
Phosphorylated
inositol
lipids

PX

Phox
homology
domain

RHEB

Ras
homologue
enriched
in
brain

SH2

Src
homology
region
2
domain

SH3

Src
homology
region
3
domain

SHP-­-1

SH2
domain-­-containing
Inositol
Phosphatase-­-1

SHP-­-2

SH2
domain-­-containing
Inositol
Phosphatase-­-2

SGK1

Serum-­-
and
glucocorticoid-­-inducible
kinase
(SGK)
1

SLE

Systemic
Lupus
Erythematosus

TCR

T
cell
receptor,
antigen
receptor
of
T
lymphocytes

Tfh

Follicular
helper
T
cells

TNF

Tumor
necrosis
factor

TSC1,
TSC2
Tuberous
sclerosis
complex
proteins
1
and
2

Treg

CD4+
regulatory
T
lymphocytes

TRIM

T
cell
receptor
(TCR)-­-interacting
molecule

WD
repeat
WD40
repeat,
ß-­-transducin
repeat

PI3K
inhibitors

A66

PI3K
inhibitor,
p110a

PI3K
inhibitor,
p110?

AS-­-605240

PI3K
inhibitor,
p110a/?

AS-­-604850

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