Page 125 - 80_01

Class
I
phosphoinositide
3-­-kinases
in
immunity…

ADDENDA:
ABBREVIATIONS
AND
LIST
OF
PI3K
INHIBITORS

Abbreviations

ABD

Adaptor
binding
domain

AIA

Adjuvant-­-induced
arthritis

Akt

Protein
kinase
B

ATG13
Autophagy-­-related
protein
13

ATM

Ataxia-­-telangiectasia
mutated
protein
(ATM)

ATR

Ataxia-­-
and
Rad3-­-related
protein
(ATR)

BAD

Bcl-­-2-­-associated
death
promoter

BCAP

B-­-cell
adaptor
for
PI3K

BCL6

B
cell
lymphoma
6
transcription
repressor

BCR

B
cell
receptor,
antigen
receptor
of
B
lymphocytes

BH

BCR-­-homology
GTPase
activation
domain

Btk

Bruton’s
tyrosine
kinase

BTLA

B-­-and
T-­-lymphocyte
attenuator,
CD272

CIA

Collagen-­-induced
arthritis

CNS

Central
nervous
system

CTLA-­-4
Cytotoxic
T-­-Lymphocyte
Antigen
4,
CD152

DNA-­-PKcs
DNA-­-dependent
protein
kinase
catalytic
subunit

EAE

Experimental
Autoimmune
Encephalomyelitis

Erk

Extracellular
signal-­-regulated
kinase

FLS

Fibroblast-­-like
synoviocyte

FYVE
F
ab
1
(yeast
orthologue
of
PIKfyve),
YOTB,
Vac
1
(vesicle
transport

protein),
and
EEA1
domain

FOXO

forkhead
transcription
factor/forkhead
box
O
transcription
factors

GAP

GTPase
activating
factors

GC

Germinal
center

GEF

Guanine
nucleotide
exchange
factors

G
proteins
Heterotrimeric
Guanine
nucleotide-­-binding
proteins

GPCR

G
protein–coupled
receptor

GSK-­-3

Glycogen
synthase
kinase
3

ICOS

Inducible
costimulator,
CD278

ITAM

Immunoreceptor
Tyrosine-­-based
activation
motif

Itk

Interleukin-­-2-­-inducible
T-­-cell
tyrosine
kinase

IKK

HEAT

I?B
kinase

LAT

Huntington,
Elongation
Factor
3,
PR65/A,
TOR
domains

MAPK

Linker
of
activation
of
T
cells

MHC

Mitogen
activated
protein
kinase

MOG

Major
Histocompatibility
Complex

Myelin
Oligodendrocyte
Glycoprotein

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