Page 120 - 80_01
P. 120
José
María
Rojo,
Pilar
Portolés
49.
Tzenaki,
N.;
&
Papakonstanti,
E.
A.
p110d
PI3
kinase
pathway:
emerging
roles
in
cancer.
Front
Oncol
3,
40
(2013).
50.
Barber,
D.
F.;
Alvarado--Kristensson,
M.;
Gonzalez--Garcia,
A.;
Pulido,
R.;
&
Carrera,
A.
C.
PTEN
regulation,
a
novel
function
for
the
p85
subunit
of
Phosphoinositide
3--Kinase.
Science
STKE
2006,
pe49--50
(2006).
51.
Downward,
J.;
&
Weigelt,
B.
Genomic
determinants
of
PI3K
pathway
inhibitor
response
in
cancer.
Front
Oncol
2,
109
(2012).
52.
Rommel,
C.;
Camps,
M.;
&
Ji,
H.
PI3Kd
and
PI3K?:
Partners
in
crime
in
inflammation
in
rheumatoid
arthritis
and
beyond?
Nat
Rev
Immunol
7,
191--201
(2007).
53.
Gamper,
C.
J.;
&
Powell,
J.
D.
All
PI3Kinase
signaling
is
not
mTOR:
Dissecting
mTOR--
dependent
and
independent
signaling
pathways
in
T
cells.
Front
Immunol
3
(2012).
54.
Thomson,
A.
W.;
Turnquist,
H.
R.;
&
Raimondi,
G.
Immunoregulatory
functions
of
mTOR
inhibition.
Nat
Rev
Immunol
9,
324--337
(2009).
55.
Ghigo,
A.;
Damilano,
F.;
Braccini,
L.;
&
Hirsch,
E.
PI3K
inhibition
in
inflammation:
Toward
tailored
therapies
for
specific
diseases.
BioEssays
32,
185--196
(2010).
56.
Okkenhaug,
K.;
Ali,
K.;
&
Vanhaesebroeck,
B.
Antigen
receptor
signalling:
A
distinctive
role
for
the
p110d
isoform
of
PI3K.
Trends
Immunol
28,
80--87
(2007).
57.
Fruman,
D.
A.;
Snapper,
S.
B.;
Yballe,
C.
M.;
Davidson,
L.;
Yu,
J.
Y.;
Alt,
F.
W.;
&
Cantley,
L.
C.
Impaired
B
cell
development
and
proliferation
in
absence
of
phosphoinositide
3--kinase
p85a
Science
283,
393--397
(1999).
58.
Suzuki,
H.;
Terauchi,
Y.;
Fujiwara,
M.;
Aizawa,
S.;
Yazaki,
Y.;
Kadowaki,
T.;
&
Koyasu,
S.
Xid--
like
immunodeficiency
in
mice
with
disruption
of
the
p85a
subunit
of
phosphoinositide
3--
kinase.
Science
283,
390--392
(1999).
59.
Chen,
D.;
Mauvais--Jarvis,
F.;
Bluher,
M.;
Fisher,
S.
J.;
Jozsi,
A.;
Goodyear,
L.
J.;
Ueki,
K.;
&
al.
p50a/p55a
phosphoinositide
3--kinase
knockout
mice
exhibit
enhanced
insulin
sensitivity.
Mol
Cell
Biol
24,
320--329
(2004).
60.
Deane,
J.
A.;
Trifilo,
M.
J.;
Yballe,
C.
M.;
Choi,
S.;
Lane,
T.
E.;
&
Fruman,
D.
A.
Enhanced
T
cell
proliferation
in
mice
lacking
the
p85ß
subunit
of
phosphoinositide
3--kinase.
J
Immunol
172,
6615--6625
(2004).
61.
Matheu,
M.
P.;
Deane,
J.
A.;
Parker,
I.;
Fruman,
D.
A.;
&
Cahalan,
M.
D.
Class
IA
phosphoinositide
3--kinase
modulates
basal
lymphocyte
motility
in
the
lymph
node.
J
Immunol
179,
2261--2269
(2007).
62.
Suire,
S.;
Condliffe,
A.
M.;
Ferguson,
G.
J.;
Ellson,
C.
D.;
Guillou,
H.;
Davidson,
K.;
Welch,
H.;
&
al.
Gß?s
and
the
Ras
binding
domain
of
p110?
are
both
important
regulators
of
PI3K?
signalling
in
neutrophils.
Nat
Cell
Biol
8,
1303--1309
(2006).
63.
Ramadani,
F.;
Bolland,
D.
J.;
Garcon,
F.;
Emery,
J.
L.;
Vanhaesebroeck,
B.;
Corcoran,
A.
E.;
&
Okkenhaug,
K.
The
PI3K
isoforms
p110a
and
p110d
are
essential
for
pre--B
cell
receptor
signaling
and
B
cell
development.
Sci
Signal
3,
ra60
(2010).
64.
Clayton,
E.;
Bardi,
G.;
Bell,
S.
E.;
Chantry,
D.;
Downes,
C.
P.;
Gray,
A.;
Humphries,
L.
A.;
&
al.
A
crucial
role
for
the
p110d
subunit
of
phosphatidylinositol
3--kinase
in
B
cell
development
and
activation.
J
Exp
Med
196,
753--763
(2002).
65.
Jou,
S.--T.;
Carpino,
N.;
Takahashi,
Y.;
Piekorz,
R.;
Chao,
J.--R.;
Carpino,
N.;
Wang,
D.;
&
al.
Essential,
nonredundant
role
for
the
phosphoinositide
3--kinase
p110d
in
signaling
by
the
B--cell
receptor
complex.
Mol
Cell
Biol
22,
8580--8591
(2002).
66.
Okkenhaug,
K.;
Bilancio,
A.;
Farjot,
G.;
Priddle,
H.;
Sancho,
S.;
Peskett,
E.;
Pearce,
W.;
&
al.
Impaired
B
and
T
cell
antigen
receptor
signaling
in
p110d
PI
3--kinase
mutant
mice.
Science
297,
1031--1034
(2002).
67.
Zhang,
T.--t.;
Okkenhaug,
K.;
Nashed,
B.
F.;
Puri,
K.
D.;
Knight,
Z.
A.;
Shokat,
K.
M.;
Vanhaesebroeck,
B.;
&
al.
Genetic
or
pharmaceutical
blockade
of
p110d
phosphoinositide
3--kinase
enhances
IgE
production.
J
Allergy
Clin
Immunol
122,
811--819.e812
(2008).
68.
Zhang,
T.--t.;
Makondo,
K.
J.;
&
Marshall,
A.
J.
p110d
phosphoinositide
3--kinase
represses
IgE
switch
by
potentiating
BCL6
expression.
J
Immunol
188,
3700--3708
(2012).
69.
Sasaki,
T.;
Irie--Sasaki,
J.;
Jones,
R.
G.;
Oliveira--dos--Santos,
A.
J.;
Stanford,
W.
L.;
Bolon,
B.;
Wakeham,
A.;
&
al.
Function
of
PI3K?
in
thymocyte
development,
T
cell
activation,
and
neutrophil
migration.
Science
287,
1040--1046
(2000).
70.
Ji,
H.;
Rintelen,
F.;
Waltzinger,
C.;
Bertschy
Meier,
D.;
Bilancio,
A.;
Pearce,
W.;
Hirsch,
E.;
&
al.
Inactivation
of
PI3K?
and
PI3Kd
distorts
T--cell
development
and
causes
multiple
organ
inflammation.
Blood
110,
2940--2947
(2007).
118
