Page 118 - 80_01
P. 118
José
María
Rojo,
Pilar
Portolés
7.
Lees--Miller,
S.
P.
PIKK--ing
a
new
partner:
A
new
role
for
PKB
in
the
DNA
damage
response.
Cancer
Cell
13,
379--380
(2008).
8.
van
der
Burg,
M.;
Ijspeert,
H.;
Verkaik,
N.
S.;
Turul,
T.;
Wiegant,
W.
W.;
Morotomi--Yano,
K.;
Mari,
P.--O.;
&
al.
A
DNA--PKcs
mutation
in
a
radiosensitive
T--B--
SCID
patient
inhibits
Artemis
activation
and
nonhomologous
end--joining.
J
Clin
Invest
119,
91--98
(2009).
9.
Knight,
Z.
A.;
Gonzalez,
B.;
Feldman,
M.
E.;
Zunder,
E.
R.;
Goldenberg,
D.
D.;
Williams,
O.;
Loewith,
R.;
&
al.
A
pharmacological
map
of
the
PI3--K
family
defines
a
role
for
p110a
in
Insulin
signaling.
Cell
125,
733--747
(2007).
10.
Kurig,
B.;
Shymanets,
A.;
Bohnacker,
T.;
Prajwal;
Brock,
C.;
Ahmadian,
M.
R.;
Schaefer,
M.;
&
al.
Ras
is
an
indispensable
coregulator
of
the
class
IB
phosphoinositide
3--kinase
p87/p110?.
Proc
Natl
Acad
Sci
USA
106,
20312--20317
(2009).
11.
Huang,
C.--H.;
Mandelker,
D.;
Schmidt--Kittler,
O.;
Samuels,
Y.;
Velculescu,
V.
E.;
Kinzler,
K.
W.;
Vogelstein,
B.;
&
al.
The
structure
of
a
human
p110a/p85a
complex
elucidates
the
effects
of
oncogenic
PI3Ka
mutations.
Science
318,
1744--1748
(2007).
12.
Backer,
J.
M.
The
regulation
of
Class
IA
PI
3--Kinases
by
inter--subunit
interactions.
In
Rommel,
C.;
Vanhaesebroeck,
B.;
&
Vogt,
P.
K.,
Editors.
In
Phosphoinositide
3--kinase
in
Health
and
Disease;
Springer
Berlin
Heidelberg,
2010;
p.
87--114.
13.
Fruman,
D.
A.
Regulatory
Subunits
of
Class
IA
PI3K.
In
Rommel,
C.;
Vanhaesebroeck,
B.;
&
Vogt,
P.
K.,
Editors.
In
Phosphoinositide
3--kinase
in
Health
and
Disease;
Springer
Berlin
Heidelberg,
2010;
p.
225--244.
14.
Acosta,
Y.;
Zafra,
M.;
Ojeda,
G.;
Bernardone,
I.;
Dianzani,
U.;
Portolés,
P.;
&
Rojo,
J.
Biased
binding
of
class
IA
phosphatidyl
inositol
3--kinase
subunits
to
inducible
costimulator
(CD278).
Cell
Mol
Life
Sci
68,
3065--3079
(2011).
15.
Delgado,
P.;
Cubelos,
B.;
Calleja,
E.;
Martinez--Martin,
N.;
Cipres,
A.;
Merida,
I.;
Bellas,
C.;
&
al.
Essential
function
for
the
GTPase
TC21
in
homeostatic
antigen
receptor
signaling.
Nat
Immunol
10,
880--888
(2009).
16.
Rodriguez--Viciana,
P.;
Sabatier,
C.;
&
McCormick,
F.
Signaling
specificity
by
Ras
family
GTPases
is
determined
by
the
full
spectrum
of
effectors
they
regulate.
Mol
Cell
Biol
24,
4943--4954
(2004).
17.
Parry,
R.
V.;
Riley,
J.
L.;
&
Ward,
S.
G.
Signalling
to
suit
function:
tailoring
phosphoinositide
3--kinase
during
T--cell
activation.
Trends
Immunol
28,
161--168
(2007).
18.
Huang,
Y.
H.;
&
Sauer,
K.
Lipid
signaling
in
T--cell
development
and
function.
Cold
Spring
Harb
Perspect
Biol
2,
a002428
(2010).
19.
Ward,
S.
G.;
&
Blunt,
M.
D.
Pharmacological
targeting
of
phosphoinositide
lipid
kinases
and
phosphatases
in
the
immune
system:
Success,
disappointment
and
new
opportunities.
Front
Immunol
3,
226
(2012).
20.
Fos,
C.;
Salles,
A.;
Lang,
V.;
Carrette,
F.;
Audebert,
S.;
Pastor,
S.;
Ghiotto,
M.;
&
al.
ICOS
ligation
recruits
the
p50a
PI3K
regulatory
subunit
to
the
Immunological
Synapse.
J
Immunol
181,
1969--1977
(2008).
21.
Ward,
S.
G.;
&
Cantrell,
D.
A.
Phosphoinositide
3--kinases
in
T
lymphocyte
activation.
Curr
Opinion
Immunol
13,
332--338
(2001).
22.
So,
L.;
&
Fruman,
D.
A.
PI3K
signalling
in
B--
and
T--lymphocytes:
new
developments
and
therapeutic
advances.
Biochem
J
442,
465--481
(2012).
23.
Guillermet--Guibert,
J.;
Bjorklof,
K.;
Salpekar,
A.;
Gonella,
C.;
Ramadani,
F.;
Bilancio,
A.;
Meek,
S.;
&
al.
The
p110ß
isoform
of
phosphoinositide
3--kinase
signals
downstream
of
G
protein--
coupled
receptors
and
is
functionally
redundant
with
p110?.
Proc
Natl
Acad
Sci
USA
105,
8292--8297
(2008).
24.
Alcazar,
I.;
Marques,
M.;
Kumar,
A.;
Hirsch,
E.;
Wymann,
M.;
Carrera,
A.
C.;
&
Barber,
D.
F.
Phosphoinositide
3
kinase?
participates
in
T
cell
receptor
induced
T
cell
activation.
J
Exp
Med
204,
2977--2987
(2007).
25.
Nombela--Arrieta,
C.;
Lacalle,
R.
A.;
Montoya,
M.
C.;
Kunisaki,
Y.;
Megías,
D.;
Marqués,
M.;
Carrera,
A.
C.;
&
al.
Differential
requirements
for
DOCK2
and
Phosphoinositide--3--Kinase
?
during
T
and
B
lymphocyte
homing.
Immunity
21,
429--441
(2004).
26.
Reif,
K.;
Okkenhaug,
K.;
Sasaki,
T.;
Penninger,
J.
M.;
Vanhaesebroeck,
B.;
&
Cyster,
J.
G.
Cutting
edge:
Differential
roles
for
Phosphoinositide
3--Kinases,
p110?
and
p110d,
in
lymphocyte
chemotaxis
and
homing.
J
Immunol
173,
2236--2240
(2004).
27.
Manning,
B.
D.;
&
Cantley,
L.
C.
AKT/PKB
signaling:
Navigating
downstream.
Cell
129,
1261--1274
(2007).
116
