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An. R. Acad. Nac. Farm., 2008, 74 (4):
________Revisión_________
Role of G protein-coupled receptor kinase 2 (GRK2)
in migration and inflammation
Recibido el 28 de mayo de 2008
PETRONILA PENELA, CRISTINA MURGA, CATALINA RIBAS,
ALICIA SALCEDO, MARÍA JURADO-PUEYO, IVETTE AYMERICH
AND FEDERICO MAYOR JR*
Departamento de Biología Molecular and Centro de Biología Molecular
“Severo Ochoa” (CSIC-UAM). Universidad Autónoma de Madrid.
Madrid, Spain.
ABSTRACT
G protein-coupled receptor kinase 2 (GRK2) emerges as a key modulator of G
protein-coupled receptors and other plasma membrane receptors triggered by chemotactic
messengers. In addition, GRK2 has been reported to interact with a variety of signal
transduction proteins related to cell migration. Interestingly, the levels of expression and
activity of this kinase are altered in several inflammatory disorders, thus suggesting that it
may play an important role in the onset or progression of these pathologies. This review
summarizes the mechanisms involved in the control of GRK2 expression and function and
highlights novel functional interactions of this protein that might help to explain how
altered GRK2 levels affects cell migration in different cell types and pathological settings.
Key words: GPCR.- Arrestins.- GIT.- p38MAPK.- MEK.
* Contacto:
Dr. Federico Mayor, Jr.
Departamento de Biología Molecular and Centro de Biología Molecular “Severo Ochoa”
(CSIC-UAM). Universidad Autónoma de Madrid.
E-28049 Madrid, Spain
Phone: +34-91-497-4865; Fax +34-91-196-4420; e-mail: fmayor@cbm.uam.es
