Page 59 - 74_04
P. 59
VOL. 74 (4) PROSTANOIDS ACTIONS IN CARDIOVASCULAR...
synthase and PGE synthase is a major determinant of atherosclerotic plaque
instability in humans. Arterioscler. Thromb. Vasc. Biol. 24: 1259-1265.
(88) BOMBARDIER, C.; LAINE, L.; REICIN, A.; SHAPIRO, D.; BURGOS-VARGAS, R.;
DAVIS, B.; DAY, R.; FERRAZ, M. B.; HAWKEY, C. J.; HOCHBERG, M. C.;
KVIEN, T. K. AND SCHNITZER, T. J. (2000) Comparison of upper
gastrointestinal toxicity of rofecoxib and naproxen in patients with
rheumatoid arthritis. VIGOR Study Group. N. Engl. J. Med. 343: 1520-1528,
1522 p following 1528.
(89) MCGETTIGAN, P. AND HENRY, D. (2006) Cardiovascular risk and inhibition of
cyclooxygenase: a systematic review of the observational studies of selective
and nonselective inhibitors of cyclooxygenase 2. Jama. 296: 1633-1644.
(90) CALDWELL, B.; ALDINGTON, S.; WEATHERALL, M.; SHIRTCLIFFE, P. AND
BEASLEY, R. (2006) Risk of cardiovascular events and celecoxib: a systematic
review and meta-analysis. J. R. Soc. Med. 99: 132-140.
(91) KEARNEY, P. M.; BAIGENT, C.; GODWIN, J.; HALLS, H.; EMBERSON, J. R. AND
PATRONO, C. (2006) Do selective cyclo-oxygenase-2 inhibitors and traditional
non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis?
Meta-analysis of randomised trials. BMJ. 332: 1302-1308.
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