Page 34 - 74_04

I. NIETO-VÁZQUEZ Y COLS. AN. R. ACAD. NAC. FARM

secretion and induced insulin resistance in adipocyte: prevention by
rosiglitazone. Biochem. Biophys. Res. Commun. 311: 372-379.
(34) HISCOCK, N.; FISCHER, C. P.; SACCHETTI, M.; VAN HALL, G.; FEBBRAIO, M. A.
AND PEDERSEN, B. K. (2005) Recombinant human interleukin-6 infusion
during low-intensity exercise does not enhance whole body lipolysis or fat
oxidation in humans. Am. J. Physiol. Endocrinol. Metab. 289: E2-7.
(35) SENN, J. J.; KLOVER, P. J.; NOWAK, I. A. AND MOONEY, R. A. (2002)
Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 51:
3391-3399.
(36) KELLER, P.; KELLER, C.; CAREY, A. L.; JAUFFRED, S.; FISCHER, C. P.;
STEENSBERG, A.; AND PEDERSEN, B. K. (2003) Interleukin-6 production by
contracting human skeletal muscle: autocrine regulation by IL-6. Biochem.
Biophys. Res. Commun. 310: 550-554.
(37) KELLY, M.; KELLER, C.; AVILUCEA, P. R.; KELLER, P.; LUO, Z.; XIANG, X.;
GIRALT, M.; HIDALGO, J.; SAHA, A. K.; PEDERSEN, B. K. AND RUDERMAN, N.
B. (2004) AMPK activity is diminished in tissues of IL-6 knockout mice: the
effect of exercise. Biochem. Biophys. Res. Commun. 320: 449-54.
(38) BRUCE, C.R. AND DYCK, D. J. (2004) Cytokine regulation of skeletal muscle
fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-alpha.
Am. J. Physiol. Endocrinol. Metab. 287: E616-E621.
(39) DIRADOURIAN, C.; GIRARD, J. AND PEGORIER, J. P. (2005) Phosphorylation of
PPARs: from molecular characterization to physiological relevance.
Biochimie. 87: 33-8.
(40) MOLLER, D. E. AND BERGER, J. P. (2003) Role of PPARs in the regulation of
obesity-related insulin sensitivity and inflammation. Int. J. Obes. Relat.
Metab. Disord. 27 Suppl 3: S17-21
(41) MUOIO, D. M.; MACLEAN, P. S.; LANG, D. B.; LI, S.; HOUMARD, J. A.; WAY, J.
M.; WINEGAR, D. A.; CORTON, J. C.; DOHM, G. L. AND KRAUS, W. E. (2002)
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal
muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-
out mice. Evidence for compensatory regulation by PPAR delta. J. Biol.
Chem. 277: 26089-97.
(42) WANG, C.; MAO, X.; WANG, L.; LIU, M.; WETZEL, M. D.; GUAN, K. L.; DONG,
L. Q. AND LIU, F. (2007) Adiponectin sensitizes insulin signaling by reducing
p70 S6 kinase-mediated serine phosphorylation of IRS-1. J. Biol. Chem. 282:
7991-7996.
(43) TANAKA, T.; YAMAMOTO, J.; IWASAKI, S.; ASABA, H.; HAMURA, H.; IKEDA, Y.;
WATANABE, M.; MAGOORI, K.; IOKA, R. X.; TACHIBANA, K.; WATANABE, Y.;
UCHIYAMA, Y.; SUMI, K.; IGUCHI, H.; ITO, S.; DOI, T.; HAMAKUBO, T.; NAITO,
M.; AUWERX, J.; YANAGISAWA, M.; KODAMA, T. AND SAKAI, J. (2003)
Activation of peroxisome proliferator-activated receptor delta induces fatty
acid betaoxidation in skeletal muscle and attenuates metabolic syndrome.
Proc. Natl. Acad. Sci. U S A. 100: 15924-9.

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