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VOL. 70 (4), 905-931, 2004 EJE CEREBRO-INTESTINAL: OREXINAS

(9) ELLACOTT, K. I. J. AND CONE, R. D. (2004) The Central melanocortin system and
the integration of short and long term regulators of energy homeostasis.
Recent Progr. Horm. Res. 395-408.

(10) KIRCHGESSNER, A. I. Orexin in the brain.gut axis (2002), Endocrin Rev. 23 (1):
1-15.

(11) SAKURAI, T.; AMEMIYA, A.; ISHII, M.; MATSUZAKI, I. et al. (1998) Orexins and
orexin receptors: a family of hypothalamic neuropeptides and G-protein-
coupled receptors that regulate feeding behaviour, Cell 92: 573-85.

(12) SAKURAI, T.; ORIGUCHI, T.; FURUYA, K. et al. (1999) Structure and function of
human prepro-orexin gene, J. Biol Chem. 274: 17771-76.

(13) LECEA, L.; KILDUFF, T. S.; PEYRON, C.; GAO, X-B.; FOYE, P. E. et al. (1998) The
hypocretins: Hypothalamus specific peptides with neuroexcitatory activity
Proc. Natl. Acad. Sci. USA 95: 322-2.

(14) LIN, L.; FARACO, J.; LI, R.; KADOTANI, H. et al. (1999) The sleep disorder canine
narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2
gene, Cell 98: 365-76.

(15) TAHERI, S.; ZEITZER, J. M.; MIGNOT, E. (2002) The role of hypocretins (orexins)
in the sleep regulation and narcolepsy. Annu. Rev. Neurosci. 25: 283-313.

(16) KIRCHGESSNER, A. L. AND LIU, M-T. (1999) Orexin synthesis and response in the
gut, Neuron 24: 941-51.

(17) GERSHON, M. D.; KIRCHGESSNER, A. L.; WADE, P. R. (1994) Functional anatomy
of the enteric nervous system In: Johnson LR ed Physiology of the gastroin-
testinal tract 3 rd, ed. New York Raven Press: 381-422.

(18) BRAY, G. A. (2000) Afferent signals regulating food intake Proc. Nutr. 59:
373-84.

(19) SCHWARTZ, G. J. (2000) The role of gastrointestinal vagal afferents in the
control of food intake: current prospects, Nutrition 16: 866-73.

(20) PEYRON, C.; TIGHE, D. K.; VAN DEN POL, A. N. et al. (1998) Neurons containing
hypocretin (orexins) project to multiple neuronal systems, J. Neurosci. 18:
9996-10015.

(21) NOWAK, K. W.; MACKOWIAK, P.; SWITONSKA, M. M. et al. (2000) Acute orexin
effects on insulin secretion in the rat: in vivo and in vitro studies, Life Sci.
66: 449-54.

(22) BERBARDIS, L. L.; BELLINGER, L. L. (1996) The lateral hypothalamic area revi-
sited: ingestive behavior, Neurosci. Biobehav, Rev. 20: 189-287.

(23) LEVITT, D. R.; TEITELBAUM, P. (1975) Somnolence akinesia, and sensory acti-
vation of motivated behavior in the lateral hypothalamic syndrome, Proc.
Natl. Acad. Sci. USA 72(7): 2819-23.

(24) DANGUIR, J. AND NICOLAIDIS, S. (1980) Cortical activity and sleep in the rat
lateral hypothalamic syndrome Brain Research 185: 305-21.

(25) ESTABROOKE, I. K.; MCCARTHY, M. T.; KO, E.; CHOU, T. et al. Orexin neuron
activity varies with bahavioral state J. Neurosci. En prensa.

(26) CHAMELLI, R. M.; WILLIE, J. T.; SINTON, C. M. et al. (1999) Narcolepsy in orexin
knockout mice: molecular genetics of sleep regulation, Cell 98: 437-51.

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